Guo Xiaoyang, Nie Fan, Jiang Haojing, Che Sitong, Liao Hai-Bing, Xu Jing, Guo Yuanqiang
State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China.
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China.
Int J Biol Macromol. 2025 Apr;304(Pt 1):140382. doi: 10.1016/j.ijbiomac.2025.140382. Epub 2025 Jan 27.
A heteropolysaccharide, designated JYP70-1, was extracted and purified from the fruits of Rosa laevigata, exhibiting a molecular weight of 1.90 × 10 g/mol. Structural analysis revealed that JYP70-1 was composed of eleven sugar residues, including α-l-Araf-(1→, →3)-α-l-Araf-(1→, →5)-α-l-Araf-(1→, →3,5)-α-l-Araf-(1→, →2,5)-α-l-Araf-(1→, →4)-α-d-Galp-(1→, →6)-β-d-Galp-(1→, →6)-α-d-Glcp-(1→, α-d-Glcp-(1→, →2)-α-d-Manp-(1→, and →3,6)-β-d-Manp-(1→. Following the characterization of the primary structure and conformation of JYP70-1, a series of biological activity assessments were executed, revealing that JYP70-1 significantly inhibited tumor growth and metastasis in a concentration-dependent manner in vivo. Furthermore, a comprehensive array of experiments was strategically designed to elucidate the anti-tumor mechanisms of JYP70-1, focusing on tumor cell migration, angiogenesis, and immune modulation. The identification of the homogeneous polysaccharide JYP70-1 presents a promising candidate for therapeutic applications in oncology.
从金樱子果实中提取并纯化出一种杂多糖，命名为JYP70-1，其分子量为1.90×10 g/mol。结构分析表明，JYP70-1由11个糖残基组成，包括α-l-阿拉伯呋喃糖-(1→、→3)-α-l-阿拉伯呋喃糖-(1→、→5)-α-l-阿拉伯呋喃糖-(1→、→3,5)-α-l-阿拉伯呋喃糖-(1→、→2,5)-α-l-阿拉伯呋喃糖-(1→、→4)-α-d-半乳糖-(1→、→6)-β-d-半乳糖-(1→、→6)-α-d-葡萄糖-(1→、α-d-葡萄糖-(1→、→2)-α-d-甘露糖-(1→以及→3,6)-β-d-甘露糖-(1→。在对JYP70-1的一级结构和构象进行表征之后，进行了一系列生物活性评估，结果显示JYP70-1在体内以浓度依赖性方式显著抑制肿瘤生长和转移。此外，还精心设计了一系列实验来阐明JYP70-1的抗肿瘤机制，重点关注肿瘤细胞迁移、血管生成和免疫调节。同质多糖JYP70-1的鉴定为肿瘤学治疗应用提供了一个有前景的候选物。
