Mohebbi Alisa, Mohammadzadeh Saeed, Moradi Zahra, Mohammadi Afshin, Poustchi Hossein, Tavangar Seyed Mohammad
Universal Scientific Education and Research Network (USERN), Tehran, Iran.
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
BMC Med Imaging. 2025 Jan 30;25(1):32. doi: 10.1186/s12880-025-01565-9.
To evaluate the staging performance of positron emission tomography/magnetic resonance imaging (PET/MRI) for confirmed esophageal cancer based on the TNM classification system as well as compare it to other alternative modalities (e.g., endoscopic ultrasonography (EUS), computed tomography (CT), MRI, and PET/CT) in a full head-to-head manner.
Protocol was pre-registered a priori at ( http://osf.io/6qj5m/ ). We searched PubMed, Web of Science, Embase, and Cochrane Library for studies until September 10, 2024. The risk of bias was assessed using Modified Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) and Quality Assessment of Diagnostic Accuracy Studies-Comparative (QUADAS-C). The classification performance of PET/MRI in T, N, and M staging of esophageal cancer and resectability status were evaluated and compared to other relative modalities. Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) was used for certainty evaluation.
Nine studies were included with 245 esophageal cancer patients. For T, N, and M staging, PET/MRI showed 9.1%, 2.0%, and 10.7% upstaging than the histopathological evaluation while these numbers were 19.4%, 12.4%, and 5.3% for downstaging. For direct comparison with PET/CT, PET/MRI showed 0.7% and 5.6% less downstaging and upstaging for N staging and 2.5% and 4.0% for M staging. As for predicting resectability status, pre-ADCmean and post-ADCmean were promising, unlike other parameters (i.e., ΔADCmean, pre-SUVmax, post-SUVmax, and ΔSUVmax).
With protocol adjustments, PET/MRI might be utilized in the future for preoperative staging of esophageal cancer.
N/A.
基于TNM分类系统评估正电子发射断层扫描/磁共振成像（PET/MRI）对确诊食管癌的分期性能，并将其与其他替代检查方法（如内镜超声检查（EUS）、计算机断层扫描（CT）、MRI和PET/CT）进行全面的直接比较。
纳入9项研究，共245例食管癌患者。对于T、N和M分期，PET/MRI显示分期上调的比例分别比组织病理学评估高9.1%、2.0%和10.7%，而分期下调的比例分别为19.4%、12.4%和5.3%。与PET/CT直接比较，PET/MRI在N分期的分期下调和上调比例分别低0.7%和5.6%，在M分期分别低2.5%和4.0%。至于预测可切除性状态，术前平均表观扩散系数（ADCmean）和术后ADCmean很有前景，这与其他参数（即ΔADCmean、术前最大标准摄取值（SUVmax）、术后SUVmax和ΔSUVmax）不同。
通过方案调整，PET/MRI未来可能用于食管癌的术前分期。
无。
