Goggin Kevin E, Seo SeonYeong Jamie, Wu Benjamin G, Ivelja Sinisa, Kugler Matthias C, Chang Miao, Darawshy Fares, Li Yonghua, Chung Cecilia J, Kyeremateng Yaa, Tsay Jun-Chieh J, Singh Shivani, Sterman Daniel H, Segal Leopoldo N, Egilmez Nejat K, Li Qingsheng
Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, Kentucky.
Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York University (NYU) Langone Health, New York, New York.
Cancer Prev Res (Phila). 2025 Apr 1;18(4):223-234. doi: 10.1158/1940-6207.CAPR-24-0159.
The role of dietary fiber in colon cancer prevention remains controversial. We investigated its impact on antitumor immunity and the gut microbiota in APCmin/+ mice infected with enterotoxigenic Bacteroides fragilis. Mice were fed high-fiber, low-fiber, or chow diets, and the tumor burden, survival, cytokines, microbiota, and metabolites were analyzed. Contrary to the belief that high fiber inhibits tumor progression, it had no significant impact compared with chow diet. However, the low-fiber diet significantly reduced the tumor burden and improved survival. Mechanistically, high fiber increased proinflammatory cytokines and CD4+Foxp3+RORγt+IL-17A+ regulatory T cells, whereas low fiber enhanced anti-inflammatory cytokines and cytotoxic T cells. High fiber enriched microbial taxa associated with IL-17A+RORγt+ regulatory T cells and altered metabolites, including reduced tryptophan and increased short-chain fatty acids and bile acids. Low fiber produced opposite effects. These findings suggest that dietary fiber's effects on colon cancer depends on microbial infection and immune status, emphasizing the need for personalized dietary interventions in colon cancer management. Prevention Relevance: Dietary fiber's impact on colon cancer progression highlights the need for personalized dietary approaches, considering microbial infection and immune status.
膳食纤维在预防结肠癌方面的作用仍存在争议。我们研究了其对感染产肠毒素脆弱拟杆菌的APCmin/+小鼠抗肿瘤免疫和肠道微生物群的影响。给小鼠喂食高纤维、低纤维或普通饮食，并分析肿瘤负担、生存率、细胞因子、微生物群和代谢产物。与高纤维抑制肿瘤进展的观点相反，与普通饮食相比，高纤维对肿瘤进展没有显著影响。然而，低纤维饮食显著降低了肿瘤负担并提高了生存率。从机制上讲，高纤维增加了促炎细胞因子和CD4+Foxp3+RORγt+IL-17A+调节性T细胞，而低纤维增强了抗炎细胞因子和细胞毒性T细胞。高纤维丰富了与IL-17A+RORγt+调节性T细胞相关的微生物分类群并改变了代谢产物，包括色氨酸减少、短链脂肪酸和胆汁酸增加。低纤维产生相反的效果。这些发现表明，膳食纤维对结肠癌的影响取决于微生物感染和免疫状态，强调了在结肠癌管理中进行个性化饮食干预的必要性。预防相关性：膳食纤维对结肠癌进展的影响凸显了考虑微生物感染和免疫状态采取个性化饮食方法的必要性。
