Kolte Deepak, Kalsi Harjit Singh, Kharkar Viraj Rajeev, Patil Tejal, Kumar Barun, Wagh Ashvin, Sachdev Sanpreet Singh
Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth (Deemed to be University), Dental College and Hospital, Navi Mumbai, Maharashtra, India.
Department of Oral Pathology and Microbiology, Bharati Vidyapeeth (Deemed to be) University Dental College and Hospital, Navi Mumbai, Maharashtra, India.
J Pharm Bioallied Sci. 2024 Dec;16(Suppl 4):S3898-S3900. doi: 10.4103/jpbs.jpbs_1330_24. Epub 2024 Dec 10.
Lignocaine, commonly used for local anesthesia, often results in discomfort during mandibular premolar extractions due to limited tissue diffusion with the buccal infiltration technique. Articaine, with better lipid solubility, promises improved diffusion and patient comfort. This study compares the efficacy of 2% Lignocaine and 4% Articaine in reducing pain during mandibular premolar extractions.
A split-mouth, randomized, controlled trial included 40 patients, aged between 18 and 40 years, undergoing bilateral mandibular premolar extractions. Each patient received 4% Articaine with adrenaline and 2% Lignocaine with adrenaline on opposite sides at separate appointments. Pain was assessed using the Visual Analog Scale (VAS) and Faces Pain Scale (FPS).
Patients in the Articaine group reported significantly lower pain levels (mean FPS: 0.2) compared to the Lignocaine group (mean FPS: 3.6) ( < 0.001). In the Articaine group, 34 out of 40 patients experienced no pain, whereas all patients in the Lignocaine group reported mild to severe pain. Mild pain was reported by 23 patients in the Lignocaine group, and moderate pain by 12 ( < 0.05). No severe pain was recorded in the Articaine group.
Articaine demonstrated superior pain control, making it a more effective choice over Lignocaine for mandibular premolar extractions using the buccal infiltration technique.
利多卡因常用于局部麻醉,在下颌前磨牙拔除术中,由于颊侧浸润技术导致组织扩散有限,常引起不适。阿替卡因具有更好的脂溶性,有望改善扩散并提高患者舒适度。本研究比较了2%利多卡因和4%阿替卡因在下颌前磨牙拔除术中减轻疼痛的效果。
一项双盲、随机、对照试验纳入了40例年龄在18至40岁之间、正在接受双侧下颌前磨牙拔除术的患者。每位患者在不同时间分别在两侧接受含肾上腺素的4%阿替卡因和含肾上腺素的2%利多卡因。使用视觉模拟量表(VAS)和面部疼痛量表(FPS)评估疼痛程度。
与利多卡因组(平均FPS:3.6)相比,阿替卡因组患者报告的疼痛程度显著更低(平均FPS:0.2)(<0.001)。在阿替卡因组中,40例患者中有34例无疼痛,而利多卡因组的所有患者均报告有轻至重度疼痛。利多卡因组有23例患者报告轻度疼痛,12例报告中度疼痛(<0.05)。阿替卡因组未记录到重度疼痛。
阿替卡因显示出更好的疼痛控制效果,使其在使用颊侧浸润技术进行下颌前磨牙拔除术时比利多卡因更有效。