Qu Jia-Yan, Lu Jing-Bo, Sun Hui-Jun, Meng Cai-Ping, Rong Li-Yuan
Nursing Department, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine.
Shanghai Clinical Research and Trial Center, Shanghai Tech University, Shanghai, China.
Eur J Cancer Prev. 2025 Feb 14. doi: 10.1097/CEJ.0000000000000952.
Male breast cancer (MBC) contributes to approximately 1% of total breast cancer diagnoses, with rapidly rising incidence and mortality rates worldwide. Since most breast cancer research has focused on women, this study intended to report the incidence, mortality, and disability-adjusted life years (DALYs) of MBC to aid in its control and prevention. The data on the incidence, DALYs, deaths, and age-standardized rates of MBC between 1990 and 2021 in different countries and territories were sourced from the Global Burden of Disease (GBD) 2021 study. In 1990 and 2021, Eastern Sub-Saharan Africa had the highest incidence, DALYs, and mortality rates. Countries in the middle socio-demographic index quintile showed the fastest growth in age-standardized incidence rate, ASDR, and ASMR. From 1990 to 2021, the incidence, mortality rate, and DALYs of MBC increased worldwide. Alcohol use, dietary risks, and tobacco use were risk factors for ASMR, with dietary risks ranking first in all GBD regions. The rise in the number of cases of breast cancer in men places substantial stress on humans. Hence, policymakers should establish effective interventions and strategies for patients with MBC in accordance with the local situation.
男性乳腺癌（MBC）约占乳腺癌确诊病例总数的1%，在全球范围内其发病率和死亡率正在迅速上升。由于大多数乳腺癌研究都集中在女性身上，本研究旨在报告男性乳腺癌的发病率、死亡率和伤残调整生命年（DALYs），以助力其控制和预防。1990年至2021年期间不同国家和地区男性乳腺癌的发病率、伤残调整生命年、死亡人数及年龄标准化率的数据来源于《2021年全球疾病负担（GBD）研究》。1990年和2021年，撒哈拉以南非洲东部的发病率、伤残调整生命年和死亡率最高。社会人口学指数处于中间五分位数的国家，其年龄标准化发病率、年龄标准化死亡率（ASDR）和年龄标准化死亡专率（ASMR）增长最快。1990年至2021年期间，全球男性乳腺癌的发病率、死亡率和伤残调整生命年均有所上升。饮酒、饮食风险和吸烟是年龄标准化死亡专率的风险因素，饮食风险在所有全球疾病负担地区中排名第一。男性乳腺癌病例数的增加给人类带来了巨大压力。因此，政策制定者应根据当地情况为男性乳腺癌患者制定有效的干预措施和策略。
