Asghari Hanjani Nazanin, Arzhang Pishva, Azadbakht Leila
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, PO Box: 1416643931, Tehran, Iran.
Qods Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
BMC Nutr. 2025 Feb 13;11(1):42. doi: 10.1186/s40795-025-01010-8.
Oral nutrition supplement (ONS) prescription in older adults is affordable for preventing malnutrition through the use of multiple nutrients and energy products. However, there is a gap in knowledge regarding the benefits of ONS supplementation on anthropometric and functional parameters in malnourished older adults without complicated conditions, known as community-dwelling older people.
Electronic databases, including PubMed/Medline, SCOPUS, Web of Science, and the Cochrane Central Register of Controlled Trials, were searched to answer this question through August 10, 2023. The study adhered to the PRISMA guidelines and was registered on PROSPERO. The Cochrane risk of bias tool assessed the quality of randomized controlled trials (RCTs). The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) tool was used to evaluate the certainty of evidence. In total, 12 RCTs (n = 1320) were initially included.
ONS had a positive effect on body weight (weighted mean difference (WMD): 1.33, 95% CI: 0.94, 1.72, P = 0.00) with moderate certainty, BMI (WMD: 0.36, 95% CI: 0.06, 0.68, P = 0.02), calf circumference (WMD: 0.27, 95% CI: 0.08, 0.46, P < 0.001) with low certainty and midarm circumference (WMD: 0.38, 95% CI: -0.14, 0.89, P = < 0.15, I2: 87.2 P < 0.00) with very low certainty. Significant improvements in grip strength (WMD: 1.012, 95% CI: 0.37, 1.65, P < 0.00) and a slightly positive change in gait speed (WMD: 0.04, 95% CI: 0.004.0.083, P = 0.03, I2:0.0, P:0.72) were also observed.
ONS in community-dwelling older persons without complicated conditions can also have beneficial effects in terms of anthropometric and functional parameters.
老年人口服营养补充剂（ONS）的处方通过使用多种营养素和能量产品来预防营养不良是经济实惠的。然而，对于无复杂疾病的营养不良老年人（即社区居住的老年人），关于ONS补充对人体测量和功能参数的益处，目前存在知识差距。
检索电子数据库，包括PubMed/Medline、SCOPUS、科学网和Cochrane对照试验中央注册库，以回答该问题，检索截至2023年8月10日。该研究遵循PRISMA指南，并在PROSPERO上注册。Cochrane偏倚风险工具评估随机对照试验（RCT）的质量。使用推荐分级、评估、制定和评价（GRADE）工具来评估证据的确定性。最初共纳入12项RCT（n = 1320）。
ONS对体重有积极影响（加权平均差（WMD）：1.33，95%置信区间：0.94，1.72，P = 0.00），确定性为中等；对BMI有影响（WMD：0.36，95%置信区间：0.06，0.68，P = 0.02），确定性为低；对小腿围有影响（WMD：0.27，95%置信区间：0.08，0.46，P < 0.001），确定性为低；对中臂围有影响（WMD：0.38，95%置信区间：-0.14，0.89，P = < 0.15，I²：87.2，P < 0.00），确定性非常低。握力也有显著改善（WMD：1.012，95%置信区间：0.37，1.65，P < 0.00），步速有轻微的正向变化（WMD：0.04，95%置信区间：0.004，0.083，P = 0.03，I²：0.0，P：0.72）。
对于无复杂疾病的社区居住老年人，ONS在人体测量和功能参数方面也可产生有益影响。
