脊柱关节炎患者氨基酸和脂质代谢失调
Dysregulation of amino acid and lipid metabolism in patients with spondyloarthritis.
作者信息
Remus Constantin, Hoffmeister Meike, Strathmeyer Selina, Heelemann Steffen, Claus Inga, Dammermann Werner, Ritter Oliver, Patschan Daniel, Patschan Susann
机构信息
Department of Internal Medicine I - Cardiology, Nephrology and Internal Intensive Medicine, Brandenburg University Hospital, Brandenburg Medical School (Theodor Fontane), 14770 Brandenburg an der Havel, Germany.
Institute of Biochemistry, Brandenburg Medical School (Theodor Fontane), 14770 Brandenburg an der Havel, Germany.
出版信息
J Int Med Res. 2025 Feb;53(2):3000605251313949. doi: 10.1177/03000605251313949.
OBJECTIVE
To conduct a metabolomics analysis in patients with spondyloarthritis (SpA) and compare results with those from healthy controls. The overall goal was to identify small-molecule substances that may have potential pathogenic and diagnostic significance in SpA.
METHODS
This was an observational, cross-sectional, single-centre study that included patients with axial (ankylosing spondylitis [AS]), peripheral (psoriatic arthritis [PsA]) and healthy controls.
RESULTS
The study included 50 patients with AS, 50 patients with PsA, and 164 controls. When compared with healthy controls, patients with SpA showed significant differences in 35 metabolites, primarily associated with amino acid and lipid metabolism. However, only two differences were found between the AS and PsA cohorts (glucose and glycerol).
CONCLUSIONS
Our data suggest that patients with SpA exhibit significant disruptions in amino acid and lipid metabolism. The large number of identified metabolites offers promising opportunities, both for discovering new SpA biomarkers and for gaining a deeper understanding of the pathophysiology of these chronic inflammatory diseases.
目的
对脊柱关节炎（SpA）患者进行代谢组学分析，并将结果与健康对照者的结果进行比较。总体目标是鉴定出可能在SpA中具有潜在致病和诊断意义的小分子物质。
方法
这是一项观察性、横断面、单中心研究，纳入了轴向型（强直性脊柱炎[AS]）、外周型（银屑病关节炎[PsA]）患者以及健康对照者。
结果
该研究纳入了50例AS患者、50例PsA患者和164例对照者。与健康对照者相比，SpA患者在35种代谢物上存在显著差异，主要与氨基酸和脂质代谢有关。然而，在AS和PsA队列之间仅发现了两处差异（葡萄糖和甘油）。
结论
我们的数据表明，SpA患者在氨基酸和脂质代谢方面存在显著紊乱。大量已鉴定的代谢物为发现新的SpA生物标志物以及更深入了解这些慢性炎症性疾病的病理生理学提供了有前景的机会。
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