Enhancing Chest X-ray Diagnosis with a Multimodal Deep Learning Network by Integrating Clinical History to Refine Attention.

The rapid advancements of deep learning technology have revolutionized medical imaging diagnosis. However, training these models is often challenged by label imbalance and the scarcity of certain diseases. Most models fail to recognize multiple coexisting diseases, which are common in real-world clinical scenarios. Moreover, most radiological models rely solely on image data, which contrasts with radiologists' comprehensive approach, incorporating both images and other clinical information such as clinical history and laboratory results. In this study, we introduce a Multimodal Chest X-ray Network (MCX-Net) that integrates chest X-ray images and clinical history texts for multi-label disease diagnosis. This integration is achieved by combining a pretrained text encoder, a pretrained image encoder, and a pretrained image-text cross-modal encoder, fine-tuned on the public MIMIC-CXR-JPG dataset, to diagnose 13 diverse lung diseases on chest X-rays. As a result, MCX-Net achieved the highest macro AUROC of 0.816 on the test set, significantly outperforming unimodal baselines such as ViT-base and ResNet152, which scored 0.747 and 0.749, respectively (p < 0.001). This multimodal approach represents a substantial advancement over existing image-based deep-learning diagnostic systems for chest X-rays.