Selbo Pål Kristian, Korbelik Mladen
Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Integrative Oncology Department, BC Cancer, Vancouver, BC, Canada.
Photochem Photobiol Sci. 2025 Feb;24(2):227-234. doi: 10.1007/s43630-025-00690-2. Epub 2025 Feb 19.
In this perspective, we present and discuss pre-clinical and some clinical studies demonstrating that local photodynamic therapy (PDT) per se is a treatment modality that can induce systemic anti-tumour immunity, however, the anti-tumour efficacy is strongly enhanced when PDT is combined with other treatment modalities, e.g., vaccines or ICI therapy. PDT has been recognized for over 30 years as a modality inducing strong immune effects in treated tumours. More recently, PDT has become perceived as a distinct type of immunogenic antitumor modality with an attractive potential for use as unique form of clinical cancer immunotherapy. It can be argued that PDT-inflicted tumour tissue injury provokes in situ vaccination effect. In the end of this perspective paper, we express our opinion of challenges and future directions in the field of PDT and PDT + immunotherapy.
从这个角度出发，我们展示并讨论临床前及一些临床研究，这些研究表明局部光动力疗法（PDT）本身就是一种能够诱导全身抗肿瘤免疫的治疗方式，然而，当PDT与其他治疗方式（如疫苗或免疫检查点抑制剂疗法）联合使用时，抗肿瘤疗效会显著增强。三十多年来，PDT一直被认为是一种在治疗肿瘤中能诱导强烈免疫效应的方式。最近，PDT已被视为一种独特类型的免疫原性抗肿瘤方式，具有作为临床癌症免疫疗法独特形式的诱人潜力。可以说，PDT造成的肿瘤组织损伤引发了原位疫苗接种效应。在这篇观点文章的结尾，我们阐述了对PDT及PDT +免疫疗法领域挑战和未来方向的看法。
