Kebamo Tamirat Ersino, Tantu Abinet, Solomon Yenealem, Walano Getachew Alemu
School of Medical Laboratory Sciences, College of Health Sciences and Medicine, Wolaita Sodo University, Wolaita Sodo, Ethiopia.
School of Medical Laboratory Sciences, College of Health and Medical Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
BMC Endocr Disord. 2025 Feb 20;25(1):47. doi: 10.1186/s12902-025-01851-1.
Thyroid diseases are the most common endocrine disorders worldwide. Thyroid hormones are essential for lipid synthesis, metabolism, and mobilization. Lipid levels in the blood may be altered when there is thyroid dysfunction. Lipid changes are linked to hyperthyroidism and primarily involve total and low-density lipoprotein cholesterol. The serum lipid profile is negatively impacted by hypothyroidism, which may increase the risk of atherosclerotic disease development. Thus, hypothyroidism constitutes a significant cause of secondary dyslipidemia. However, the results obtained from different studies are inconsistent, and there are few data regarding lipid profiles in thyroid dysfunction patients in the study area. Therefore, this study aimed to assess the lipid profile of thyroid dysfunction patients at Wolaita Sodo University Comprehensive Specialized Hospital from May 1 to June 15, 2021.
A comparative cross-sectional study was conducted involving 200 participants (100 thyroid dysfunction patients and 100 age- and sex-matched controls). Socio-demographic and related data were collected from the study participants via a pretested structured questionnaire through face-to-face interviews. Independent sample T tests and Mann‒Whitney U tests were used for data analysis. P < 0.05 indicated statistical significance.
Out of 200 study participants 40 (20%) hyperthyroid, 60 (30%) hypothyroidism, and 100 (50%) controls. In individuals with hyperthyroidism, the levels of triglycerides, total cholesterol, and low-density lipoprotein cholesterol were significantly lower than those in the control group. Compared to the control group, the hypothyroidism patients had significantly higher levels of triglycerides, low-density lipoprotein cholesterol, total cholesterol, and high-density lipoprotein cholesterol.
The lipid profile can change significantly as a result of thyroid dysfunction. Biochemical screening of lipid profiles is essential for improving patients with thyroid dysfunction with dyslipidemia.
甲状腺疾病是全球最常见的内分泌疾病。甲状腺激素对脂质合成、代谢和动员至关重要。甲状腺功能障碍时，血液中的脂质水平可能会改变。脂质变化与甲状腺功能亢进有关，主要涉及总胆固醇和低密度脂蛋白胆固醇。甲状腺功能减退会对血清脂质谱产生负面影响，这可能会增加动脉粥样硬化疾病发展的风险。因此，甲状腺功能减退是继发性血脂异常的重要原因。然而，不同研究的结果并不一致，且关于研究地区甲状腺功能障碍患者脂质谱的数据很少。因此，本研究旨在评估2021年5月1日至6月15日在沃莱塔索多大学综合专科医院甲状腺功能障碍患者的脂质谱。
进行了一项比较横断面研究，涉及200名参与者（100名甲状腺功能障碍患者和100名年龄和性别匹配的对照组）。通过预先测试的结构化问卷，通过面对面访谈从研究参与者中收集社会人口学和相关数据。采用独立样本T检验和曼-惠特尼U检验进行数据分析。P < 0.05表示具有统计学意义。
在200名研究参与者中，40名（20%）甲状腺功能亢进，60名（30%）甲状腺功能减退，100名（50%）为对照组。甲状腺功能亢进患者的甘油三酯、总胆固醇和低密度脂蛋白胆固醇水平显著低于对照组。与对照组相比，甲状腺功能减退患者的甘油三酯、低密度脂蛋白胆固醇、总胆固醇和高密度脂蛋白胆固醇水平显著更高。
甲状腺功能障碍可导致脂质谱发生显著变化。对脂质谱进行生化筛查对于改善合并血脂异常的甲状腺功能障碍患者至关重要。
