Steinsapir J, Rojas A M, Alarcón O, Tchernitchin A N
Acta Endocrinol (Copenh). 1982 Feb;99(2):263-71. doi: 10.1530/acta.0.0990263.
Oestradiol induces uterine eosinophilia and oedema, both in the intact immature rat and in the adult ovariectomized rat. These responses are decreased in ovariectomized-adrenalectomized adult rats, in adrenalectomized immature rats and in medullectomized immature rats. Pre-treatment with L-epinephrine restored both oestrogenic effects. Insulin inhibits oestrogen binding by uterine eosinophils and concurrently decreases oestrogen-induced uterine oedema and eosinophilia. These phenomena do not occur with inactive insulin. Insulin also induces blood eosinopaenia, suggesting an explanation for the findings in the uterus.
雌二醇可在未成熟的完整大鼠和成年去卵巢大鼠中诱导子宫嗜酸性粒细胞增多和水肿。在成年去卵巢-肾上腺切除大鼠、肾上腺切除的未成熟大鼠和延髓切除的未成熟大鼠中，这些反应会减弱。用L-肾上腺素预处理可恢复这两种雌激素效应。胰岛素可抑制子宫嗜酸性粒细胞与雌激素的结合，并同时减轻雌激素诱导的子宫水肿和嗜酸性粒细胞增多。这些现象在无活性胰岛素处理时不会出现。胰岛素还会导致血液嗜酸性粒细胞减少，这为子宫中的发现提供了解释。
