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负载有来自山核桃壳残渣的黑色素的电纺膜用于皮肤护理应用。

Electrospun Membranes Loaded with Melanin Derived from Pecan Nutshell () Residues for Skin-Care Applications.

作者信息

García-García Michell, Jaime-Ferrer Jesús Salvador, Medrano-Lango Fernanda Nayeli, Quintana-Rodríguez Elizabeth, Campos-García Tonatiu, Rodríguez-Sevilla Erika, Orona-Tamayo Domancar

机构信息

CIATEC A.C., Centro de Innovación Aplicada en Tecnologías Competitivas, Omega 201, Industrial Delta, León C.P. 37545, Guanajuato, Mexico.

Unidad Profesional Interdisciplinaria de Ingeniería Campus Guanajuato, Instituto Politécnico Nacional, Av. Mineral de Valenciana 200, Col. Fraccionamiento Industrial Puerto Interior, Silao de la Victoria C.P. 36275, Guanajuato, Mexico.

出版信息

Membranes (Basel). 2025 Feb 3;15(2):44. doi: 10.3390/membranes15020044.

DOI:10.3390/membranes15020044
PMID:39997671
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11857193/
Abstract

This study investigates the incorporation of melanin extracted from pecan nutshell residues into a polyacrylonitrile (PAN) matrix during the electrospinning of microfiber membranes. Melanin concentrations of 0.5, 2.0, and 5.0% / were incorporated to enhance the physicochemical and biological properties of the fibers. The melanin-loaded PAN fibers exhibited significant antioxidant activity against DPPH and ABTS radicals, with scavenging rates ranging from 46.58% to 62.77% and 41.02% to 82.36%, respectively, while unmodified PAN fibers showed no activity. Furthermore, the melanin-loaded membranes demonstrated antimicrobial effects. The membranes also exhibited an important enzyme inhibition activity against collagenase (37%), hyaluronidase (22%), tyrosinase (36%), and elastase (33%). Molecular docking studies reveal different potential amino acids of the active sites of aging enzymes that interact strongly with melanin pigment, particularly collagenase, followed by hyaluronidase, tyrosinase, and elastase. These results suggest that the novel melanin-loaded PAN membranes possess promising bioactive properties with potential applications in different skin-care applications.

摘要

本研究调查了在制备微纤维膜的静电纺丝过程中，将从山核桃壳残渣中提取的黑色素掺入聚丙烯腈（PAN）基质的情况。分别掺入浓度为0.5%、2.0%和5.0%的黑色素，以增强纤维的物理化学和生物学性能。负载黑色素的PAN纤维对DPPH和ABTS自由基表现出显著的抗氧化活性，清除率分别为46.58%至62.77%和41.02%至82.36%，而未改性的PAN纤维则没有活性。此外，负载黑色素的膜表现出抗菌作用。这些膜还对胶原酶（37%）、透明质酸酶（22%）、酪氨酸酶（36%）和弹性蛋白酶（33%）表现出重要的酶抑制活性。分子对接研究揭示了与黑色素强烈相互作用的衰老酶活性位点的不同潜在氨基酸，尤其是胶原酶，其次是透明质酸酶、酪氨酸酶和弹性蛋白酶。这些结果表明，新型负载黑色素的PAN膜具有有前景的生物活性特性，在不同的皮肤护理应用中具有潜在应用价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb7c/11857193/72d8e20ec17a/membranes-15-00044-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb7c/11857193/5a96c2457a91/membranes-15-00044-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb7c/11857193/5694ba0943bc/membranes-15-00044-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb7c/11857193/f79d54060ed5/membranes-15-00044-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb7c/11857193/dc507e3979f7/membranes-15-00044-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb7c/11857193/64152ea3bf2f/membranes-15-00044-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb7c/11857193/dda64c312bff/membranes-15-00044-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb7c/11857193/cd6657920748/membranes-15-00044-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb7c/11857193/302b0bba4090/membranes-15-00044-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb7c/11857193/503dc712dc17/membranes-15-00044-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb7c/11857193/c8400dde1bbe/membranes-15-00044-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb7c/11857193/72d8e20ec17a/membranes-15-00044-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb7c/11857193/5a96c2457a91/membranes-15-00044-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb7c/11857193/5694ba0943bc/membranes-15-00044-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb7c/11857193/f79d54060ed5/membranes-15-00044-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb7c/11857193/dc507e3979f7/membranes-15-00044-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb7c/11857193/64152ea3bf2f/membranes-15-00044-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb7c/11857193/dda64c312bff/membranes-15-00044-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb7c/11857193/cd6657920748/membranes-15-00044-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb7c/11857193/302b0bba4090/membranes-15-00044-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb7c/11857193/503dc712dc17/membranes-15-00044-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb7c/11857193/c8400dde1bbe/membranes-15-00044-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb7c/11857193/72d8e20ec17a/membranes-15-00044-g011.jpg

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