Wang Zhen, Xiang Penghui, Xu Zhe, Gu Meiqi, Zhang Rui, Li Yifei, Chen Hua, He Li, Yi Chengla
Department of Traumatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Department of Orthopaedic Trauma, Chinese PLA General Hospital (301 Hospital), Beijing 100853, China.
Bioengineering (Basel). 2025 Feb 18;12(2):201. doi: 10.3390/bioengineering12020201.
Osteoporotic fractures represent a significant public health challenge in the context of an aging global population, with the rising prevalence of osteoporosis intensifying the demand for effective fracture treatment. Restoring the structure and function of bone tissue damaged by osteoporosis-induced defects remains a critical issue in clinical practice. In recent years, bioactive metallic materials such as magnesium, zinc, and strontium have gained considerable attention due to their exceptional mechanical properties, biocompatibility, and biodegradability, positioning them as promising materials for osteoporotic fracture repair. This review systematically explored the biological mechanisms, application advancements, and associated challenges of magnesium, zinc, and strontium in fracture healing. Key topics included their roles in promoting osteoblast proliferation and differentiation, inhibiting osteoclast activity, and modulating the bone microenvironment. Additionally, this review examined the optimization strategies for their clinical application, such as their integration into bone scaffolds, the functionalization of conventional materials, and the synergistic effects between different metals. Finally, this review analyzed the current progress and unresolved issues in this field, offering a forward-looking perspective on the clinical potential of bioactive metallic materials in precision treatment of osteoporotic fractures.
在全球人口老龄化的背景下，骨质疏松性骨折是一项重大的公共卫生挑战，随着骨质疏松症患病率的上升，对有效骨折治疗的需求也日益增加。恢复因骨质疏松症导致的骨组织缺损所破坏的骨组织结构和功能，仍然是临床实践中的关键问题。近年来，镁、锌和锶等生物活性金属材料因其优异的力学性能、生物相容性和生物降解性而备受关注，使其成为骨质疏松性骨折修复的有前景材料。本综述系统地探讨了镁、锌和锶在骨折愈合中的生物学机制、应用进展及相关挑战。关键主题包括它们在促进成骨细胞增殖和分化、抑制破骨细胞活性以及调节骨微环境中的作用。此外，本综述还研究了它们临床应用的优化策略，如将它们整合到骨支架中、传统材料的功能化以及不同金属之间的协同效应。最后，本综述分析了该领域的当前进展和未解决的问题，对生物活性金属材料在骨质疏松性骨折精准治疗中的临床潜力提供了前瞻性展望。
