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富含骨抑素和间充质干细胞的生物材料在骨质疏松症兔中的成骨潜力。

Osteogenic Potential of a Biomaterial Enriched with Osteostatin and Mesenchymal Stem Cells in Osteoporotic Rabbits.

机构信息

Orthopaedics and Traumatology Service, Hospital Universitario Fundación Jiménez Díaz, 28040 Madrid, Spain.

Orthopedics and Traumatology Service, Hospital Universitario 12 de Octubre & Imas12, 28041 Madrid, Spain.

出版信息

Biomolecules. 2024 Jan 23;14(2):143. doi: 10.3390/biom14020143.

DOI:10.3390/biom14020143
PMID:38397380
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10887093/
Abstract

Mesoporous bioactive glasses (MBGs) of the SiO-CaO-PO system are biocompatible materials with a quick and effective in vitro and in vivo bioactive response. MBGs can be enhanced by including therapeutically active ions in their composition, by hosting osteogenic molecules within their mesopores, or by decorating their surfaces with mesenchymal stem cells (MSCs). In previous studies, our group showed that MBGs, ZnO-enriched and loaded with the osteogenic peptide osteostatin (OST), and MSCs exhibited osteogenic features under in vitro conditions. The aim of the present study was to evaluate bone repair capability after large bone defect treatment in distal femur osteoporotic rabbits using MBGs (76%SiO-15%CaO-5%PO-4%ZnO (mol-%)) before and after loading with OST and MSCs from a donor rabbit. MSCs presence and/or OST in scaffolds significantly improved bone repair capacity at 6 and 12 weeks, as confirmed by variations observed in trabecular and cortical bone parameters obtained by micro-CT as well as histological analysis results. A greater effect was observed when OST and MSCs were combined. These findings may indicate the great potential for treating critical bone defects by combining MBGs with MSCs and osteogenic peptides such as OST, with good prospects for translation to clinical practice.

摘要

介孔生物活性玻璃（MBGs）是一种具有生物相容性的 SiO-CaO-PO 系统材料，具有快速有效的体外和体内生物活性响应。MBGs 可以通过在其组成中包含治疗活性离子、在其介孔中容纳成骨分子或通过在其表面修饰间充质干细胞（MSCs）来增强。在之前的研究中，我们的研究小组表明，富含 ZnO 并负载成骨肽骨抑素（OST）的 MBGs 和 MSCs 在体外条件下表现出成骨特征。本研究的目的是使用 MBGs（76%SiO-15%CaO-5%PO-4%ZnO（摩尔%））评估骨质疏松兔股骨远端大骨缺损治疗后的骨修复能力，MBGs 分别在负载 OST 和供体兔 MSCs 前后。MSC 的存在和/或支架中的 OST 显著提高了 6 周和 12 周时的骨修复能力，这可以通过微 CT 获得的小梁和皮质骨参数以及组织学分析结果观察到的变化得到证实。当 OST 和 MSCs 结合使用时，效果更大。这些发现可能表明，通过将 MBGs 与 MSCs 和骨生成肽（如 OST）结合使用来治疗临界骨缺损具有巨大潜力，并且有望转化为临床实践。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a331/10887093/64838e1fd982/biomolecules-14-00143-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a331/10887093/c158918d9d08/biomolecules-14-00143-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a331/10887093/1d69f0793f3b/biomolecules-14-00143-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a331/10887093/46b4fbde9987/biomolecules-14-00143-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a331/10887093/5c1f9a5b2c90/biomolecules-14-00143-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a331/10887093/f2320ee0cb6a/biomolecules-14-00143-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a331/10887093/4d20954759e0/biomolecules-14-00143-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a331/10887093/b10429f48ae0/biomolecules-14-00143-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a331/10887093/7a569e54cda5/biomolecules-14-00143-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a331/10887093/1f4c88e83b66/biomolecules-14-00143-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a331/10887093/64838e1fd982/biomolecules-14-00143-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a331/10887093/c158918d9d08/biomolecules-14-00143-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a331/10887093/294adadb397f/biomolecules-14-00143-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a331/10887093/a5fee19d2186/biomolecules-14-00143-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a331/10887093/1d69f0793f3b/biomolecules-14-00143-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a331/10887093/46b4fbde9987/biomolecules-14-00143-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a331/10887093/5c1f9a5b2c90/biomolecules-14-00143-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a331/10887093/f2320ee0cb6a/biomolecules-14-00143-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a331/10887093/4d20954759e0/biomolecules-14-00143-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a331/10887093/b10429f48ae0/biomolecules-14-00143-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a331/10887093/7a569e54cda5/biomolecules-14-00143-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a331/10887093/1f4c88e83b66/biomolecules-14-00143-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a331/10887093/64838e1fd982/biomolecules-14-00143-g012.jpg

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