Adan Mohamed Mohamoud, Hu Bowen, Yan Minbo, Hidig Sakarie Mustafe, Dai Yingbo, Li Gonghui
Department of Urology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, P.R. China.
Department of Urology, The People's Hospital of Longhua, Shenzhen, Guangdong 518000, P.R. China.
Mol Clin Oncol. 2025 Feb 18;22(4):34. doi: 10.3892/mco.2025.2829. eCollection 2025 Apr.
According to increasing evidence, high-density lipoproteins (HDLs) may raise prostate-specific antigen (PSA) levels in the prostate. The link between HDL-cholesterol (C) and PSA, on the other hand, is debatable and challenging. Hence, the present study examined the relationship between HDL-C and PSA in men using the National Health and Nutrition Examination Survey (NHANES) database. NHANES data were extracted for five cycles from 2001 to 2010. The data used for analysis included PSA concentrations, sociodemographic and laboratory data. After the screening, 6,669 out of 52,195 participants were included in the present study. Participants were divided into four groups based on HDL-C quartiles. Categorical and continuous variables using weighted chi-square tests and linear regression models were analysed to compare differences between groups. A total of three weighted multivariate linear regression models were constructed and the association between HDL-C and PSA using a smoothed curve fit was assessed. In the present study, unadjusted and adjusted multivariate linear regression models revealed a significant positive association between PSA concentrations and serum HDL-C levels. Specifically, each unit increase in HDL-C ratio was associated with an increase in PSA concentration by 0.470 ng/ml (P<0.001) in the unadjusted model. In minimally adjusted models, accounting for socioeconomic and demographic factors, this association remained significant, with an increase of 0.408 ng/ml per unit increase in serum HDL-C (P<0.001). Furthermore, the stratified analysis revealed various impacts based on socioeconomic status and HDL-C levels, with a significant interaction between household income and HDL-C levels (P=0.037). Exclusion of subjects with low HDL-C levels strengthened the association, revealing a significant increase in PSA concentration with higher HDL-C levels (0.50 ng/ml per 1 mmol/l increase, P=0.009). The findings of the present study suggest a nuanced relationship between HDL-C levels, socioeconomic factors, and PSA concentrations, highlighting the potential importance of considering these factors in prostate cancer (Pca) screening and risk assessment. The present study found a positive association between serum HDL-C and PSA concentrations in adult men in the United States without a Pca diagnosis.
越来越多的证据表明，高密度脂蛋白（HDL）可能会提高前列腺中的前列腺特异性抗原（PSA）水平。另一方面，HDL胆固醇（C）与PSA之间的联系存在争议且颇具挑战性。因此，本研究利用美国国家健康与营养检查调查（NHANES）数据库，研究了男性中HDL-C与PSA之间的关系。从2001年到2010年的五个周期中提取了NHANES数据。用于分析的数据包括PSA浓度、社会人口统计学和实验室数据。经过筛选，52195名参与者中有6669名被纳入本研究。参与者根据HDL-C四分位数分为四组。使用加权卡方检验和线性回归模型对分类变量和连续变量进行分析，以比较组间差异。共构建了三个加权多元线性回归模型，并使用平滑曲线拟合评估HDL-C与PSA之间的关联。在本研究中，未调整和调整后的多元线性回归模型显示，PSA浓度与血清HDL-C水平之间存在显著正相关。具体而言，在未调整模型中，HDL-C比值每增加一个单位，PSA浓度增加0.470 ng/ml（P<0.001）。在最小调整模型中，考虑社会经济和人口因素后，这种关联仍然显著，血清HDL-C每增加一个单位，PSA浓度增加0.408 ng/ml（P<0.001）。此外，分层分析显示了基于社会经济地位和HDL-C水平的各种影响，家庭收入与HDL-C水平之间存在显著交互作用（P=0.037）。排除HDL-C水平低的受试者加强了这种关联，显示随着HDL-C水平升高，PSA浓度显著增加（每增加1 mmol/l增加0.50 ng/ml，P=0.009）。本研究结果表明HDL-C水平、社会经济因素和PSA浓度之间存在细微差别关系，突出了在前列腺癌（Pca）筛查和风险评估中考虑这些因素的潜在重要性。本研究发现，在美国未诊断为Pca的成年男性中，血清HDL-C与PSA浓度之间存在正相关。
