Life's Essential 8, Cardiovascular Health, and CKD Progression among Hispanic/Latino Adults: The Hispanic Community Health Study/Study of Latinos Study.

KEY POINTS

In US Hispanic/Latino adults with CKD, better cardiovascular health is associated with slower eGFR declines and improvements in albumin-to-creatinine ratio over 6 years. These findings support the implementation of a heart healthy lifestyle to delay CKD progression among US Hispanic/Latino adults.

BACKGROUND

The primary cause of death in CKD is cardiovascular disease. Life's essential 8 (LE8) is an established measure of cardiovascular health (CVH). Our objective was to examine the relationship between CVH (LE8 score) and CKD progression among Hispanic/Latino adults, an understudied but growing population.

METHODS

The Hispanic Community Health Study/Study of Latinos is a longitudinal cohort of Hispanic/Latino adults aged 18–74 years from four cities in the United States, examined at visit 1 (V1, 2008–2011) and visit 2 (2014–2017). At V1, participants underwent a comprehensive assessment of health behaviors (diet, physical activity, nicotine exposure, and sleep health) and clinical measurements (body mass index, blood lipids, blood glucose, and BP) used to estimate an LE8 score (range: 0–100). We included 1284 participants with CKD at V1, defined as eGFR <60 ml/min per 1.73 m and/or urine albumin-to-creatinine ratio (ACR) ≥30 mg/g. Change in eGFR and log(ACR) was defined as the difference in each measure between V1 and visit 2. To estimate the association between LE8 score with change in eGFR and log(ACR), we used linear regression models adjusted for follow-up time and demographic, socioeconomic, and clinical factors. All analyses accounted for Hispanic Community Health Study/Study of Latinos complex survey design.

RESULTS

Among 1284 Hispanic/Latino participants with CKD at V1, the mean age was 48.6 years (SEM: 0.8), 57.2% were women, and the mean LE8 score was 61.1 (SEM: 0.7). Over an average of 6 years of follow-up, eGFR declined by 5.8 ml/min per 1.73 m and log(ACR) declined by 0.60. From multivariable adjusted models, for each 10-unit higher LE8 score, eGFR was lower by 0.97 ml/min per 1.73 m less (95% confidence interval, −1.93 to −0.02) and log(ACR) was lower by an additional 0.15 (95% confidence interval, 0.05 to 0.25).

CONCLUSIONS

Among diverse US Hispanic/Latino adults with CKD, higher LE8 score (better CVH) was associated with a slower decline in eGFR and lower albuminuria over 6 years.