Department of Chemistry, School of Science, U.P. Rajarshi Tandon Open University, Prayagraj-211021, UP, India.
Functional Polymer Material Lab, Department of Chemistry, Harcourt Butler Technical University, Kanpur-208002, UP, India.
J Mater Chem B. 2024 Mar 13;12(11):2691-2710. doi: 10.1039/d3tb02562d.
Over the past two decades, metal-organic frameworks (MOFs) have garnered substantial scientific interest across diverse fields, spanning gas storage, catalysis, biotechnology, and more. Zirconium, abundant in nature and biologically relevant, offers an appealing combination of high content and low toxicity. Consequently, Zr-based MOFs have emerged as promising materials with significant potential in biomedical applications. These MOFs serve as effective nanocarriers for controlled drug delivery, particularly for challenging antitumor and retroviral drugs in cancer and AIDS treatment. Additionally, they exhibit prowess in bio-imaging applications. Beyond drug delivery, Zr-MOFs are notable for their mechanical, thermal, and chemical stability, making them increasingly relevant in engineering. The rising demand for stable, non-toxic Zr-MOFs facilitating facile nanoparticle formation, especially in drug delivery and imaging, is noteworthy. This review focuses on biocompatible zirconium-based metal-organic frameworks (Zr-MOFs) for controlled delivery in treating diseases like cancer and AIDS. These MOFs play a key role in theranostic approaches, integrating diagnostics and therapy. Additionally, their utility in bio-imaging underscores their versatility in advancing medical applications.
在过去的二十年中，金属-有机骨架（MOFs）在气体存储、催化、生物技术等多个领域引起了广泛的科学关注。锆在自然界中含量丰富，且具有生物相关性，是一种具有高含量和低毒性的理想组合。因此，Zr 基 MOFs 作为有前途的材料，在生物医学应用中具有重要的潜在应用价值。这些 MOFs 可用作控制药物释放的有效纳米载体，特别是在癌症和艾滋病治疗中用于具有挑战性的抗肿瘤和逆转录病毒药物的释放。此外，它们在生物成像应用中也表现出色。除了药物传递之外，Zr-MOFs 在机械、热和化学稳定性方面表现出色，这使得它们在工程领域的应用越来越重要。人们对稳定、无毒的 Zr-MOFs 的需求不断增加，这有利于促进易于形成纳米颗粒的药物传递和成像，这一点值得关注。本综述重点介绍了用于治疗癌症和艾滋病等疾病的生物相容性锆基金属-有机骨架（Zr-MOFs）的控制释放。这些 MOFs 在治疗方法中发挥着关键作用，将诊断和治疗结合在一起。此外，它们在生物成像中的应用凸显了它们在推进医学应用方面的多功能性。
