AlAraby Amany Ahmed, Hassabou Nadia Fathy, Shehab Eldin Wessam Ibrahim
Oral Medicine, Periodontology and Oral Radiology, Faculty of Dentistry, October 6 University, Giza, Egypt.
Oral and Maxillofacial Pathology, Faculty of Dentistry, October 6 University, Giza, Egypt.
J Tissue Viability. 2025 May;34(2):100877. doi: 10.1016/j.jtv.2025.100877. Epub 2025 Feb 25.
MEBO is an analgesic and antibacterial natural agent. Sesame oil extract plays a positive effect in wound healing that may be attributed to its ability to scavenge free radicals and antioxidant properties.
In this study, MEBO was topically applied to the site of a traumatic oral ulcer to examine its therapeutic effect on pain relief and wound healing. Patients were randomly assigned into two equal groups: group I (MEBO), group II (control), (n = 15 patients each). Pain was recorded by using the Visual Analogue Scale (VAS), wound size was measured at days 2, 5, and 10. Cytological analysis was also performed using the superficial epithelial cell and keratinization indices.
There was a statistically significant difference in VAS scores and wound size between MEBO group and control group (p ≤ 0.001). Cytological results of MEBO group showed a highly significant improvement (p ≤ 0.00001) in re-epithelization and keratinization indices over time.
Our results showed that the application of MEBO on traumatic ulcer sites has a significant improvement in wound healing and rapid enhancing effect on the re-epithelialization rate.
湿润烧伤膏（MEBO）是一种具有止痛和抗菌作用的天然制剂。芝麻油提取物在伤口愈合中发挥积极作用，这可能归因于其清除自由基的能力和抗氧化特性。
在本研究中，将湿润烧伤膏局部应用于创伤性口腔溃疡部位，以检查其对缓解疼痛和伤口愈合的治疗效果。患者被随机分为两组，每组人数相等：第一组（湿润烧伤膏组），第二组（对照组），每组各15例患者。使用视觉模拟评分法（VAS）记录疼痛情况，在第2天、第5天和第10天测量伤口大小。还使用浅表上皮细胞和角化指数进行细胞学分析。
湿润烧伤膏组与对照组之间的VAS评分和伤口大小存在统计学显著差异（p≤0.001）。湿润烧伤膏组的细胞学结果显示，随着时间推移，再上皮化和角化指数有极显著改善（p≤0.00001）。
我们的结果表明，将湿润烧伤膏应用于创伤性溃疡部位可显著促进伤口愈合，并快速提高再上皮化率。
