Aksoy M
Am J Ind Med. 1985;7(5-6):395-402. doi: 10.1002/ajim.4700070506.
There is no doubt about the leukemogenic effect of benzene in man. The evidence is as follows: (1) The incidence of leukemia in shoeworkers exposed to benzene in a period of 8 years in Istanbul was 13.6/100,000, which is significantly higher than that for leukemia in the general population. (2) Following the phase-out of benzene in Istanbul, the number of leukemic workers decreased and none were reported in the subsequent 3 years. (3) The development of leukemia in pancytopenic patients with benzene exposure was observed in 13 out of 51 patients. (4) The differences in the distribution of the types of leukemia in individuals exposed and in nonexposed groups were as follows: acute leukemia 96.1% in the former group, and 46% in the latter group. The high percentages of acute erythroleukemia and preleukemia were other interesting findings in the exposed group. (5) Two cases of leukemia were observed in a 6-year period at a tire cord manufacturing plant with 550 workers. At one location in the plant the concentration of benzene measured by gas chromatography was nearly 110 ppm. Additionally, we have studied 12 cases of malignant lymphoma, four cases of multiple myeloma, and six cases of lung cancer, all of whom were chronically exposed to benzene. The possible role of benzene in the etiology of these malignancies is discussed.
苯对人类的致白血病作用是毫无疑问的。证据如下：（1）在伊斯坦布尔，鞋厂工人在8年期间接触苯，白血病发病率为13.6/10万，显著高于普通人群的白血病发病率。（2）在伊斯坦布尔逐步淘汰苯之后，患白血病的工人数量减少，在随后3年中未报告有病例。（3）在51例接触苯的全血细胞减少症患者中，观察到13例发生白血病。（4）接触苯的个体与未接触苯的个体在白血病类型分布上的差异如下：前一组急性白血病占96.1%，后一组占46%。急性红白血病和白血病前期在接触组中的高比例是其他有趣的发现。（5）在一家有550名工人的轮胎帘线制造厂，6年期间观察到2例白血病。在该厂的一个地点，用气相色谱法测得的苯浓度接近110 ppm。此外，我们研究了12例恶性淋巴瘤、4例多发性骨髓瘤和6例肺癌患者，他们均长期接触苯。本文讨论了苯在这些恶性肿瘤病因学中的可能作用。
