Decouflé P, Blattner W A, Blair A
Environ Res. 1983 Feb;30(1):16-25. doi: 10.1016/0013-9351(83)90161-5.
A historical cohort mortality study was conducted of 259 male employees of a chemical plant where benzene has been used in large quantities. The study group included all persons who were employed by the Company any time between January 1, 1947 and December 31, 1960. The cohort was followed through December 31, 1977 at which time 58 known deaths were identified. The only unusual finding was four deaths from lymphoreticular cancers when 1.1 would have been expected on the basis of national mortality rates. Three of the deaths were due to leukemia and one was caused by multiple myeloma. In addition, one of the leukemia deaths had multiple myeloma listed on the death certificate. The findings are consistent with previous reports of leukemia following occupational exposure to benzene and raise the possibility that multiple myeloma could be linked to benzene, also.
对一家大量使用苯的化工厂的259名男性员工进行了一项历史性队列死亡率研究。研究组包括1947年1月1日至1960年12月31日期间任何时间受雇于该公司的所有人。对该队列进行随访至1977年12月31日，此时确定有58例已知死亡病例。唯一不寻常的发现是4例死于淋巴网状细胞癌，而根据全国死亡率预计应为1.1例。其中3例死亡是由白血病引起，1例由多发性骨髓瘤引起。此外，其中1例白血病死亡病例的死亡证明上列出了多发性骨髓瘤。这些发现与先前关于职业接触苯后发生白血病的报告一致，并增加了多发性骨髓瘤也可能与苯有关的可能性。
