Lipowitz A J, Wong P L, Stevens J B
Am J Vet Res. 1985 May;46(5):1166-70.
Degenerative joint disease and inflammation of the synovial membrane were produced in the left stifle of 16 dogs by severing the cranial cruciate ligament. Arthrotomy only was performed on the right stifle. Synovial membrane from these joints was histologically examined at 1, 2, 8, and 13 weeks after surgical operation. Similar tissue was obtained from 4 healthy dogs for comparison. Inflammatory changes in the synovium of the left stifle progressed with time and were prominent at 8 weeks postoperatively; subsynovial fibrosis was greatest at 13 weeks. Inflammation of the synovial membrane and subsynovial tissue was characterized by synovial cell hypertrophy and hyperplasia, plasma cell and lymphocyte infiltration, and increased vascularization of the subsynovial region.
通过切断颅交叉韧带，在16只犬的左膝关节制造退行性关节病和滑膜炎症。右膝关节仅进行关节切开术。在手术后1周、2周、8周和13周对这些关节的滑膜进行组织学检查。从4只健康犬获取相似组织作为对照。左膝关节滑膜的炎症变化随时间进展，在术后8周最为显著；滑膜下纤维化在13周时最为严重。滑膜和滑膜下组织的炎症表现为滑膜细胞肥大和增生、浆细胞和淋巴细胞浸润以及滑膜下区域血管增多。
