Wang Miao, Liu Yi Bing, Tong Wai Man, Leung Wai Keung, He Long Long, Xu Xin, Xu Dan, Zhou Qin
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.
Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.
J Clin Periodontol. 2025 Jul;52(7):1011-1023. doi: 10.1111/jcpe.14147. Epub 2025 Mar 5.
This study aims to investigate the early alterations in microbiome construction and succession around dental implants in both periodontally healthy individuals and patients with a history of periodontitis during the first month after implant-crown placement.
Ninety-five subgingival plaque samples were collected from 10 periodontally compromised patients (PCP) and nine periodontally healthy patients (PHP) at four time points with a 1-week interval and analysed using dynamic metagenomic analysis. The study compared the formation and temporal change in the peri-implant microbiome in the PCP and PHP groups during the first month after the implant crown placement. A two-year follow-up examination was conducted to assess the clinical outcomes of early peri-implant dysbiosis.
The results showed that PCP groups exhibited distinctively dysbiotic features in their peri-implant microbiome upon initial establishment, with an earlier and elevated emergence of periodontopathogens. This dysbiosis in the PCP group was associated with significantly higher modified sulcus bleeding index (mBI) scores compared with the PHP group. Neisseria was identified as a key driver of early peri-implant dysbiosis in patients with a periodontitis history.
This study established the first microbial link between periodontitis history and early peri-implant dysbiosis, highlighting the importance of early prevention strategies against peri-implant diseases in patients with a periodontitis history.
本研究旨在调查在种植体-牙冠植入后的第一个月内，牙周健康个体和有牙周炎病史的患者种植体周围微生物群结构和演替的早期变化。
从10名牙周受损患者（PCP）和9名牙周健康患者（PHP）中，在四个时间点每隔1周收集95份龈下菌斑样本，并使用动态宏基因组分析进行分析。该研究比较了种植体牙冠植入后第一个月内PCP组和PHP组种植体周围微生物群的形成和时间变化。进行了为期两年的随访检查，以评估早期种植体周围生态失调的临床结果。
结果显示，PCP组在种植体周围微生物群初步形成时表现出明显的生态失调特征，牙周病原体出现得更早且数量增加。与PHP组相比，PCP组的这种生态失调与改良龈沟出血指数（mBI）得分显著更高有关。奈瑟菌被确定为有牙周炎病史患者早期种植体周围生态失调的关键驱动因素。
本研究建立了牙周炎病史与早期种植体周围生态失调之间的首个微生物联系，强调了对有牙周炎病史的患者预防种植体周围疾病早期策略的重要性。
