Manz Andrea Stefanie, Müssig Dieter, Wegehaupt Florian, Attin Thomas, Sahrmann Philipp
Zahnklinik für Kinder und Jugendliche, Seestrasse 7, Uster, 8610, Switzerland.
Danube Private University, Steiner Landstraße 124, Krems, 3500, Austria.
BMC Oral Health. 2025 Mar 8;25(1):360. doi: 10.1186/s12903-025-05720-0.
A possible co-occurence of hypomineralizations in deciduous teeth (HD) and Molar Incisor Hypomineralization (MIH) is matter of ongoing discussion. This case control study aimed to assess whether there was a correlation between HD and MIH in a suburban Swiss population.
Patients were seen once at the age of 4-6 and a second time at 8-9 years, each, for comprehensive dental examination, including the diagnosis of HD and MIH. Appointments took place as part of routinely annual examinations in a school dental clinic of the municipality of Uster. In a retrospective approach, children with hypomineralizations in the deciduous dentition at the first appointment were defined as "cases". An identical number of age- and gender-matched "controls" without hypomineralizations were randomly chosen from the patient files. The odds ratio for MIH - as reported during the second appointment - for cases with HD compared to controls without was calculated using chi-square, quota ratio and Fisher's exact test with a level of significance of 0.05%.
In the cohort of 426 children (112 females and 101 males in each group) the overall prevalence of MIH was 11.7%, with mainly mild signs of MIH. Case patients showed 1.24 ± 0.70 teeth with HD. For the test group, the odds ratio for MIH was 1.44 as compared to the controls, failing to show statistical significance.
There might be a slightly enhanced probability for MIH if the deciduous dentition display hypomineralizations.
Given hypomineralizations in the deciduous dentition, the probability for Molar Incisor Hypomineralizations might be slightly enhanced.
乳牙矿化不全（HD）与磨牙切牙矿化不全（MIH）可能同时出现，这一问题仍在讨论中。本病例对照研究旨在评估瑞士郊区人群中HD与MIH之间是否存在相关性。
患者分别在4 - 6岁和8 - 9岁时接受一次全面的牙科检查，包括HD和MIH的诊断。这些检查是乌斯特市学校牙科诊所常规年度检查的一部分。采用回顾性研究方法，将首次就诊时乳牙列有矿化不全的儿童定义为“病例组”。从患者档案中随机选取相同数量的年龄和性别匹配、无矿化不全的“对照组”。使用卡方检验、定额比检验和费舍尔精确检验计算HD病例组与无HD对照组在第二次就诊时报告的MIH的优势比，显著性水平为0.05%。
在426名儿童队列中（每组112名女性和101名男性），MIH的总体患病率为11.7%，主要为MIH的轻度症状。病例组患者有HD的牙齿数为1.24 ± 0.70颗。与对照组相比，试验组MIH的优势比为1.44，但未显示出统计学意义。
如果乳牙列出现矿化不全，MIH的发生概率可能会略有增加。
鉴于乳牙列存在矿化不全，磨牙切牙矿化不全的发生概率可能会略有增加。
