转录因子TFIIIA的一级结构有12个连续重复序列。
The primary structure of transcription factor TFIIIA has 12 consecutive repeats.
作者信息
Brown R S, Sander C, Argos P
出版信息
FEBS Lett. 1985 Jul 8;186(2):271-4. doi: 10.1016/0014-5793(85)80723-7.
PMID:4007166
Abstract
Analysis of the amino acid sequence of transcription factor TFIIIA from Xenopus laevis reveals the presence of 12 repeating structures, each about 30 residues in length. These segments have been aligned and their secondary structure predicted. The repeats each contain two invariant cysteines and two invariant histidines, perhaps to coordinate a zinc cation. Possible nucleic acid interaction modes are discussed.
摘要
对非洲爪蟾转录因子TFIIIA的氨基酸序列分析显示存在12个重复结构，每个结构长度约为30个残基。这些片段已进行比对并预测了其二级结构。每个重复序列包含两个不变的半胱氨酸和两个不变的组氨酸，可能用于配位锌阳离子。文中讨论了可能的核酸相互作用模式。
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