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从……中发现的一种生物碱——冠狗牙花定碱的分析与特性

Analysis and characteristics of coronaridine, an alkaloid found in .

作者信息

Kisaka Hiroaki, Karakawa Sachise, Miwa Tetsuya, Hirano Hiroto, Onuki Takashi, Iyo Mayu

机构信息

Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc., 1-1, Suzuki-cho, Kawasaki-ku, Kawasaki, Kanagawa 210-8681, Japan.

出版信息

Plant Biotechnol (Tokyo). 2024 Dec 25;41(4):387-392. doi: 10.5511/plantbiotechnology.24.0717a.

DOI:10.5511/plantbiotechnology.24.0717a
PMID:40083579
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11897734/
Abstract

Coronaridine, a monoterpenoid indole alkaloid, is present in and the related species . Recent exhaustive analysis revealed its presence in , though specific details remain unknown. We conducted a detailed analysis of coronaridine in , detecting it in seedlings post-germination up to 8 weeks after sowing, with peak abundance at 3-4 weeks. Gradual decrease occurred from the flowering stage, and it was absent during seed formation. The accumulation varied dramatically with the plant's growth phase. LC-MS/MS analysis confirmed (-) coronaridine, consistent with . Additionally, cultivating at 35°C increased coronaridine accumulation over 10-fold. These findings hold potential for enhancing the stable production of iboga alkaloids for pharmaceutical use.

摘要

冠狗牙花定碱，一种单萜吲哚生物碱，存在于[植物名称1]及其相关物种中。最近的详尽分析表明它也存在于[植物名称2]中，不过具体细节仍不清楚。我们对[植物名称3]中的冠狗牙花定碱进行了详细分析，在播种后直至发芽后8周的幼苗中检测到了它，在3 - 4周时含量达到峰值。从开花阶段开始逐渐减少，在种子形成期间不存在。其积累量随植物生长阶段的变化差异很大。液相色谱 - 串联质谱分析证实了（-）冠狗牙花定碱，与[相关内容]一致。此外，在35°C下培养使冠狗牙花定碱的积累量增加了10倍以上。这些发现对于提高用于制药的伊博格生物碱的稳定产量具有潜在意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b691/11897734/49d7b740b5e0/plantbiotechnology-41-4-24.0717a-figure10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b691/11897734/5b82695c87ce/plantbiotechnology-41-4-24.0717a-figure01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b691/11897734/ab4498a960c3/plantbiotechnology-41-4-24.0717a-figure02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b691/11897734/f292944c0a53/plantbiotechnology-41-4-24.0717a-figure03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b691/11897734/fc95172b01e9/plantbiotechnology-41-4-24.0717a-figure04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b691/11897734/69178a097b76/plantbiotechnology-41-4-24.0717a-figure05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b691/11897734/a622bc34459a/plantbiotechnology-41-4-24.0717a-figure06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b691/11897734/358b33b11808/plantbiotechnology-41-4-24.0717a-figure07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b691/11897734/09c31cdc3407/plantbiotechnology-41-4-24.0717a-figure08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b691/11897734/ec38316d4837/plantbiotechnology-41-4-24.0717a-figure09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b691/11897734/49d7b740b5e0/plantbiotechnology-41-4-24.0717a-figure10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b691/11897734/5b82695c87ce/plantbiotechnology-41-4-24.0717a-figure01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b691/11897734/ab4498a960c3/plantbiotechnology-41-4-24.0717a-figure02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b691/11897734/f292944c0a53/plantbiotechnology-41-4-24.0717a-figure03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b691/11897734/fc95172b01e9/plantbiotechnology-41-4-24.0717a-figure04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b691/11897734/69178a097b76/plantbiotechnology-41-4-24.0717a-figure05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b691/11897734/a622bc34459a/plantbiotechnology-41-4-24.0717a-figure06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b691/11897734/358b33b11808/plantbiotechnology-41-4-24.0717a-figure07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b691/11897734/09c31cdc3407/plantbiotechnology-41-4-24.0717a-figure08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b691/11897734/ec38316d4837/plantbiotechnology-41-4-24.0717a-figure09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b691/11897734/49d7b740b5e0/plantbiotechnology-41-4-24.0717a-figure10.jpg

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