Wise Stephen A, Hosbas Coskun Sanem, Hayes Hugh V, Wilson Walter B, Murray Jacolin A, Lippert J Andreas, Burdette Carolyn Q, Schantz Michele M, Murphy Karen E, Christopher Steven J, Yu Lee L, Rimmer Catherine A, Pasiakos Stefan M, Kuszak Adam J
IFC Contractor in Support of the Office of Dietary Supplements (ODS), National Institutes of Health (NIH), Bethesda, MD, 20817, USA.
Kelly Government Services Contractor in Support of the Office of Dietary Supplements (ODS), National Institutes of Health (NIH), Bethesda, MD, 20817, USA.
Anal Bioanal Chem. 2025 May;417(12):2439-2471. doi: 10.1007/s00216-025-05787-2. Epub 2025 Mar 15.
For two decades, the National Institute of Standards and Technology (NIST) and the National Institutes of Health Office of Dietary Supplements have collaborated to develop dietary supplement-matrix reference materials. During the first decade, NIST developed over 20 botanical and non-botanical dietary supplement Standard Reference Materials (SRMs) using multiple analytical techniques to assign values for selected marker compounds and toxic elements. In the past decade, NIST has expanded the scope of materials available, and other producers of certified reference materials (CRMs) have joined to provide a limited number of additional materials. This review describes briefly the first decade in the development of CRMs for dietary supplements, primarily botanical dietary supplement ingredients (e.g., ginkgo, green tea, saw palmetto, St. Johns' wort, botanical oils, berries, and soy) and a popular multivitamin/multimineral (MVM) SRM. We discuss the analytical challenges in producing these materials and how these materials established a model for the next generation of CRMs. The second generation of dietary supplement CRMs/RMs, consisting primarily of botanical matrices, calibration solutions, and new and replacement MVM CRMs, is discussed in greater detail including improvements based on experiences from the first decade and potential future needs and developments in this emerging reference material research sector.
二十年来，美国国家标准与技术研究院（NIST）与美国国立卫生研究院膳食补充剂办公室合作，致力于开发膳食补充剂基质参考物质。在第一个十年里，NIST利用多种分析技术开发了20多种植物性和非植物性膳食补充剂标准参考物质（SRM），为选定的标记化合物和有毒元素赋值。在过去十年中，NIST扩大了可用材料的范围，其他有证参考物质（CRM）生产商也加入进来，提供了数量有限的其他材料。本综述简要介绍了膳食补充剂CRM开发的第一个十年，主要涉及植物性膳食补充剂成分（如银杏、绿茶、锯叶棕、圣约翰草、植物油、浆果和大豆）以及一种广受欢迎的多种维生素/多种矿物质（MVM）SRM。我们讨论了生产这些材料时遇到的分析挑战，以及这些材料如何为下一代CRM建立了一个模型。第二代膳食补充剂CRM/RM主要包括植物性基质、校准溶液以及新的和替代的MVM CRM，将更详细地进行讨论，包括基于第一个十年的经验所做的改进，以及这个新兴参考物质研究领域未来潜在的需求和发展。
