Egorova-Brumley Natalia, Khlif Mohamed Salah, Werden Emilio, Johnson Liam, Brodtmann Amy
Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Australia.
Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Australia.
Sci Rep. 2025 Mar 17;15(1):9085. doi: 10.1038/s41598-025-93149-4.
Stroke survivors experience high levels of sedentary behaviour. However, less is known about the variability in weekday-weekend patterns of sedentary behaviour and whether it is linked to cognitive performance. We examined whether there was a difference in weekend and weekday amount of time spent in sedentary and moderate-to-vigorous physical activity (MVPA) at three months post-stroke and whether there was an association between these patterns and cognitive performance at three months. We included ischaemic stroke survivors from the Cognition And Neocortical Volume After Stroke (CANVAS) cohort, with objective physical activity data estimated using the SenseWear Armband. We compared physical activity levels between 97 stroke survivors (minor severity) and 37 control participants on weekends and weekdays in sedentary and MVPA zones. We then linked these outcomes to cognitive functioning at three months. While both stroke and control groups had a comparable decrease in MVPA on weekends compared to weekdays, we observed a significant increase in sedentary activity [55 min on average (95% Confidence Interval 77 - 33) with a small effect size - partial eta squared = 0.036)] on weekends in the stroke group but not in controls. When we compared two groups of stroke participants 'more sedentary' vs. 'less sedentary'-based on weekend activity, we observed a higher proportion of stroke survivors classified as cognitively impaired vs. cognitively normal in the 'more sedentary' group. Further analysis showed the groups differed significantly on their cognitive performance, especially in the memory domain. There is a significant difference in the amount of sedentary behaviour, but not MVPA, on weekends vs. weekdays in the stroke group. Furthermore, we demonstrate that a higher amount of sedentary activity on the weekend is associated with worse cognitive performance at three months, especially on memory tasks. These results are exploratory but suggest that decreasing sedentary behaviour, especially on the weekend, could be specifically investigated as a therapeutic target to maintain better cognition after stroke.
中风幸存者久坐行为水平较高。然而，对于久坐行为在工作日 - 周末模式的变异性以及它是否与认知表现相关，我们了解得较少。我们研究了中风后三个月时，周末和工作日在久坐及中度至剧烈身体活动（MVPA）上所花费的时间是否存在差异，以及这些模式与三个月时的认知表现之间是否存在关联。我们纳入了来自中风后认知与新皮质体积（CANVAS）队列的缺血性中风幸存者，使用SenseWear臂带估算客观的身体活动数据。我们比较了97名中风幸存者（轻度严重程度）和37名对照参与者在周末和工作日久坐及MVPA区域的身体活动水平。然后我们将这些结果与三个月时的认知功能联系起来。虽然中风组和对照组在周末的MVPA与工作日相比都有类似程度的下降，但我们观察到中风组在周末久坐活动显著增加[平均55分钟（95%置信区间77 - 33），效应量较小 - 偏eta平方 = 0.036]，而对照组没有。当我们基于周末活动将两组中风参与者分为“久坐程度更高”与“久坐程度更低”进行比较时，我们观察到在“久坐程度更高”组中，被归类为认知受损的中风幸存者比例高于认知正常者。进一步分析表明，两组在认知表现上有显著差异，尤其是在记忆领域。中风组在周末与工作日的久坐行为量存在显著差异，但MVPA量没有。此外，我们证明周末较高的久坐活动量与三个月时较差的认知表现相关，尤其是在记忆任务方面。这些结果具有探索性，但表明减少久坐行为，特别是在周末，可作为维持中风后更好认知的治疗靶点进行专门研究。
