Schuckit M A
J Stud Alcohol. 1985 May;46(3):191-5. doi: 10.15288/jsa.1985.46.191.
A total of 348 consecutive primary alcoholics entering an alcoholism treatment program comprised Group 1 (172 men who were offered disulfiram and agreed to take it) and Group 2 (176 who were eligible to take the drug but refused). Information was gathered at the time of intake into the program through personal interviews with patients and two resource persons. The clinical course in the 12 months after discharge was determined by follow-up interviews with patients and one resource person. The two groups were demographically similar at intake and there were no significant differences in outcome. However, at intake those men who agreed to take disulfiram and subsequently did well were more affluent, more likely to be married and less likely to have spent time in jail prior to treatment, and drank less often than those men who refused. Thus, although agreeing to take disulfiram was not associated with an improved outcome overall, men with more social stability and less pervasive problems may be the ones most likely to benefit from the drug.
共有348名连续进入戒酒治疗项目的原发性酗酒者，其中第1组（172名男性，被提供双硫仑并同意服用）和第2组（176名符合服用该药物条件但拒绝的人）。在进入项目时，通过对患者和两名提供信息者的个人访谈收集信息。出院后12个月的临床病程通过对患者和一名提供信息者的随访访谈确定。两组在入院时人口统计学特征相似，结果无显著差异。然而，入院时同意服用双硫仑且随后情况良好的男性比拒绝服用的男性更富裕，更有可能已婚，治疗前入狱的可能性更小，饮酒频率也更低。因此，虽然总体上同意服用双硫仑与改善结果无关，但社会稳定性更高、问题更少的男性可能是最有可能从该药物中受益的人。
