Güçlü Zeynep Aslı, Gundes Nur Sultan, Temur Nimet, Ocsoy Ismail, Ildız Nilay
Department of Pediatric Dentistry, Faculty of Dentistry, Erciyes University, 38039, Melikgazi, Kayseri, Türkiye.
Department of Analytical Chemistry, Faculty of Pharmacy, Erciyes University, Kayseri, Türkiye.
Odontology. 2025 Mar 19. doi: 10.1007/s10266-025-01086-5.
Silver nanoparticles (Ag NPs) are effective universal germicides toward various pathogens. Herein, we developed synthesis of fast and stable Ag NPs with red cabbage extract (RCE) used as reducing and capping agent promoted by the LED light device used in clinics for dental polymerization and investigated their antimicrobial properties for dentistry purposes. We systematically explained the formation mechanism of anthocyanins (anth) directed, existing as main and predominant components in RCE, Ag NPs (anth@Ag NP) in 10 s (sn) under photoirradiation by LED light with a standard power mode (1000 mW/cm). We tested anth@Ag NP as an effective cavity disinfectant and caries arresting agent with its enhanced antimicrobial property against model cariogenic pathogens including standard strains of Streptococcus mutans (S. mutans) ATCC 25275, Enterococcus faecalis (E. faecalis) ATCC 29212, Staphylococcus aureus (S. aureus) ATCC 29213, and Candida albicans (C. albicans) ATCC 90028. We claim that the anth@Ag NP can be doped into several dental materials polymerized by LED light for long-term antimicrobial properties toward dental infections.
银纳米颗粒（Ag NPs）是针对多种病原体的有效通用杀菌剂。在此，我们利用临床用于牙科聚合的LED光装置，开发了以红甘蓝提取物（RCE）作为还原剂和封端剂快速稳定合成Ag NPs的方法，并研究了其用于牙科目的的抗菌性能。我们系统地解释了在标准功率模式（1000 mW/cm）的LED光照射下，10秒内花青素（anth）作为RCE中的主要和优势成分所导向的Ag NPs（anth@Ag NP）的形成机制。我们测试了anth@Ag NP作为一种有效的窝洞消毒剂和防龋剂，其对包括变形链球菌（S. mutans）ATCC 25275标准菌株、粪肠球菌（E. faecalis）ATCC 29212、金黄色葡萄球菌（S. aureus）ATCC 29213和白色念珠菌（C. albicans）ATCC 90028在内的模型致龋病原体具有增强的抗菌性能。我们声称，anth@Ag NP可以掺入几种由LED光聚合的牙科材料中，以实现对牙科感染的长期抗菌性能。
