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探索单刺仙人掌在对抗耐甲氧西林金黄色葡萄球菌方面的抗菌功效。

Exploring the antibacterial efficacy of Opuntia monacantha in combatting methicillin-resistant Staphylococcus aureus.

作者信息

Jameel Sana, Khan Mahtab Ahmad, Asif Ayesha, Hameed Huma, Ur Rahman Shafeeq, Irfan Ali, Shazly Gamal A, Bin Jardan Yousef A

机构信息

Faculty of Pharmaceutical Sciences, University of Central Punjab (UCP), Lahore, Pakistan.

Institute of Clinical and Experimental Pharmacology & Toxicology, University of Lübeck, Lübeck, Germany.

出版信息

Sci Rep. 2025 Mar 20;15(1):9552. doi: 10.1038/s41598-025-93939-w.

DOI:10.1038/s41598-025-93939-w
PMID:40108249
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11923071/
Abstract

Public health is seriously threatened by the rise of antibiotic-resistant strains of bacteria, especially methicillin resistant Staphylococcus aureus (MRSA). This study investigated the phytochemical compounds, and possible antibacterial effects of a methanolic extract of the cactus species Opuntia monacantha Haw. against MRSA. The powdered substance was extracted with methanol and filtered, and the filtrate was partitioned with n-hexane, chloroform and ethyl acetate. The fractions with higher percentage yields such as the n-hexane and chloroform fractions went through GC-MS analysis. They consist of various compounds that are known to have strong antioxidant and antimicrobial activities. The antimicrobial activity of the plant was measured via a diffusion assay. On the basis of these results, the Opuntia monacantha crude methanolic extract, and the n-hexane and chloroform fractions significantly inhibited all the MRSA strains used in the test at 100, 75 and 50 mg/mL. Furthermore, the minimum inhibitory concentrations of various fractions of the methanolic extract of Opuntia monacantha were also examined. Therefore, Opuntia could be a promising candidate for strengthening the existing formulations in pharmaceutical science for the treatment of MRSA. However, additional research is necessary before its therapeutic use is recommended. The results are intended to provide important new information for the creation of sustainable and alternative antimicrobial agents.

摘要

抗生素耐药性细菌菌株的增加，尤其是耐甲氧西林金黄色葡萄球菌（MRSA），对公共卫生构成了严重威胁。本研究调查了仙人掌物种单刺仙人掌（Opuntia monacantha Haw.）甲醇提取物的植物化学成分及其对MRSA可能的抗菌作用。将该粉末状物质用甲醇提取并过滤，滤液用正己烷、氯仿和乙酸乙酯进行分配。产率较高的馏分，如正己烷和氯仿馏分，进行了气相色谱 - 质谱分析。它们由各种已知具有强抗氧化和抗菌活性的化合物组成。通过扩散试验测定该植物的抗菌活性。基于这些结果，单刺仙人掌粗甲醇提取物以及正己烷和氯仿馏分在100、75和50mg/mL时显著抑制了测试中使用的所有MRSA菌株。此外，还检测了单刺仙人掌甲醇提取物各馏分的最低抑菌浓度。因此，在制药科学中，仙人掌可能是增强现有治疗MRSA制剂的有前途的候选物。然而，在推荐其治疗用途之前，还需要进行更多的研究。这些结果旨在为开发可持续的替代抗菌剂提供重要的新信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/998d/11923071/8d800138fdde/41598_2025_93939_Fig12_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/998d/11923071/6bfacfe04e39/41598_2025_93939_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/998d/11923071/870dd8d7ffd7/41598_2025_93939_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/998d/11923071/c1a85c182c2a/41598_2025_93939_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/998d/11923071/6231a680bac7/41598_2025_93939_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/998d/11923071/1bda2f9f544c/41598_2025_93939_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/998d/11923071/4b4c6d11bca3/41598_2025_93939_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/998d/11923071/e4b140103c68/41598_2025_93939_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/998d/11923071/8d800138fdde/41598_2025_93939_Fig12_HTML.jpg

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