Choi Byung Hee, Choi Kwanyong, Park Soo-Yeon, Kim Ji Yeon
Department of Nano Bio Engineering, Seoul National University of Science and Technology, 232, Gongneung-Ro, Nowon-Gu, Seoul, 01811 Republic of Korea.
Department of Food Science and Biotechnology, Seoul National University of Science and Technology, 232, Gongneung-Ro, Nowon-Gu, Seoul, 01811 Republic of Korea.
Food Sci Biotechnol. 2024 Dec 17;34(6):1495-1505. doi: 10.1007/s10068-024-01768-w. eCollection 2025 Apr.
Menopausal symptoms, including hot flashes, metabolic changes, and osteoporosis, significantly impact postmenopausal women. Given concerns about hormone replacement therapy, S-equol, a metabolite of the soybean isoflavone daidzein, has emerged as a potential alternative. This study explored the efficacy of S-equol-containing-supplement (SE5-OH), a fermented soy germ containing S-equol, on menopausal symptoms and osteoporosis in 6-month-old and 8-week-old ovariectomized (OVX) rat models. SE5-OH did not affect uterine weight or endometrial thickness but significantly reduced body weight in 8-week-old OVX rats (p < 0.01). SE5-OH also decreased estrogen receptor upregulation in the liver and hypothalamus. In the hypothalamus, SE5-OH downregulated calcitonin gene-related peptide levels, which are linked to hot flashes and osteoporosis (p < 0.05). Additionally, SE5-OH stabilized the bone-formation marker RANKL/OPG, tended to increase estrogen receptor levels in tibial bone tissue and increased serum bone-turnover biomarkers. In conclusion, SE5-OH may alleviate postmenopausal symptoms, including hot flashes, lipid metabolism changes, and osteoporosis.
The online version contains supplementary material available at 10.1007/s10068-024-01768-w.
潮热、代谢变化和骨质疏松等更年期症状对绝经后女性有显著影响。鉴于对激素替代疗法的担忧，大豆异黄酮黄豆苷元的代谢产物S-雌马酚已成为一种潜在的替代物。本研究探讨了含S-雌马酚的补充剂（SE5-OH），一种含有S-雌马酚的发酵大豆胚芽，对6月龄和8周龄去卵巢（OVX）大鼠模型的更年期症状和骨质疏松的疗效。SE5-OH不影响子宫重量或子宫内膜厚度，但显著降低8周龄OVX大鼠的体重（p < 0.01）。SE5-OH还降低了肝脏和下丘脑雌激素受体的上调。在下丘脑中，SE5-OH下调了与潮热和骨质疏松相关的降钙素基因相关肽水平（p < 0.05）。此外，SE5-OH稳定了骨形成标志物RANKL/OPG，倾向于增加胫骨骨组织中的雌激素受体水平，并增加血清骨转换生物标志物。总之，SE5-OH可能减轻绝经后症状，包括潮热、脂质代谢变化和骨质疏松。
在线版本包含可在10.1007/s10068-024-01768-w获取的补充材料。
