Chen Andrew C N, Treede Rolf-Detlef
Pain Research Center, Department of Psychiatry and Behavioral Sciences, Department of Oral Medicine, Department of Psychology, University of Washington, Seattle, WA 98195 U.S.A. Institute of Physiology, Hamburg University/UKE, D-2000 Hamburg 20 F.R.G.
Pain. 1985 May;22(1):67-79. doi: 10.1016/0304-3959(85)90149-6.
The McGill Pain Questionnaire (MPQ), supplemented with a German version, was administered to 10 healthy subjects to evaluate two laboratory pain models. Ischemia pain was induced as a tonic pain model and electrical intracutaneous stimuli were applied as a model of phasic pain. In addition, both pain models were employed simultaneously in order to evaluate their mutual influence. Tonic pain was rated higher than phasic pain on the affective, evaluative and miscellaneous MPQ subscales. Furthermore, the sensory descriptor choices for the two pain models were dissimilar, although the number of words chosen as well as the intensity represented by these words were of equal magnitude. These findings indicate that the sensory quality of the pain models is different and that the aversive component is much greater for the tonic pain than for the phasic pain. When applied simultaneously, tonic pain was able to inhibit phasic pain perception. This modulation could be demonstrated on visual analog scales of intensity (-44%) and aversiveness (-49%), on a 10-point category scale (-27%), and on the MPQ scores present pain intensity (PPI) (-29%), number of words chosen (NWC) (-25%) and pain rating intensity (PRI) (-28%). Differences were significant on the 5% level for the visual analog scales, the category scale and PPI. Evaluation of the MPQ subscales revealed that mainly the affective dimension of phasic pain was reduced under concurrent tonic pain. It is concluded that the MPQ is as well-suited to characterize differential analgesic effects as it is to differentiate properties of pain models.
麦吉尔疼痛问卷（MPQ），辅以德文版本，对10名健康受试者进行施测，以评估两种实验室疼痛模型。诱导缺血性疼痛作为持续性疼痛模型，并施加皮内电刺激作为阵发性疼痛模型。此外，同时采用这两种疼痛模型以评估它们的相互影响。在MPQ的情感、评估和其他子量表上，持续性疼痛的评分高于阵发性疼痛。此外，两种疼痛模型的感觉描述词选择不同，尽管所选词语的数量以及这些词语所代表的强度大小相等。这些发现表明，疼痛模型的感觉性质不同，且持续性疼痛的厌恶成分比阵发性疼痛大得多。同时应用时，持续性疼痛能够抑制阵发性疼痛的感知。这种调节在强度视觉模拟量表（-44%）和厌恶视觉模拟量表（-49%）、10点分类量表（-27%）以及MPQ的当前疼痛强度（PPI）评分（-29%）、所选词语数量（NWC）（-25%）和疼痛评分强度（PRI）（-28%）上均得到证实。视觉模拟量表、分类量表和PPI在5%水平上差异显著。对MPQ子量表的评估显示，在同时存在持续性疼痛的情况下，主要是阵发性疼痛的情感维度降低。得出的结论是，MPQ既适合表征不同的镇痛效果，也适合区分疼痛模型的特性。
