Department of Ophthalmology, 1st affiliated hospital of Xi'an Jiaotong University , Xi'an , Shaanxi , China.
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University , Xi'an , China.
Curr Eye Res. 2019 Sep;44(9):980-986. doi: 10.1080/02713683.2019.1607393. Epub 2019 Apr 29.
To assess the effect of axial length (AL) on the quantification of superficial vessel density of both macular and disc region using swept source optical coherence tomography angiography (SSOCTA). This is a cross-sectional clinical study. Seventy-five eyes from 75 Chinese healthy participants (56 females) with a mean age of 26.6 ± 6.8 (range 19-50) years were included in this study. All eyes were imaged with SSOCTA, using a 3 × 3mm scan pattern centered on the macular and optic disc, respectively, and the superficial layer was used for evaluation. The image size was corrected with AL using Bennett formula. Outcome measurements included perfusion density (PD), vessel length density (VLD) in parafoveal and disc regions, averaged peripapillary large vessel diameter and area of foveal avascular zone (FAZ). Image processing and measurements was performed using Image J software. Multivariate regression analysis adjusting for age and signal strength was used to assess the influence of AL on the metrics. AL was the only predictive factor for parafoveal PD ( = -0.273, = .047) and VLD ( = -0.396, = .003). There was no correlation between AL and area of FAZ, large vessel diameter, or the vessel density on any location in disc region. Age was the only predictor for PD ( = -0.287, = .024) and VLD ( = -0.289, = .023) on optic nerve head. AL was negatively correlated with superficial parafoveal microvasculature, but not correlated with peripapillary capillaries, suggesting that the inner retina stretches more in the distal end of the disc with increased AL.
评估眼轴（AL）对使用扫频源光学相干断层扫描血管造影术（SS-OCTA）定量评估黄斑和盘区浅层血管密度的影响。这是一项横断面临床研究。纳入 75 名中国健康志愿者（56 名女性）的 75 只眼，平均年龄为 26.6±6.8 岁（19-50 岁）。所有眼均使用 SSOCTA 进行成像，使用 3×3mm 扫描模式分别以黄斑和视盘为中心进行扫描，并使用浅层进行评估。使用 Bennett 公式根据 AL 校正图像大小。测量的结果包括黄斑旁和盘区的灌注密度（PD）、血管长度密度（VLD）、平均视乳头大血管直径和黄斑中心凹无血管区（FAZ）面积。使用 Image J 软件进行图像处理和测量。使用多元回归分析，调整年龄和信号强度，评估 AL 对各参数的影响。AL 是黄斑旁 PD（=−0.273，P=.047）和 VLD（=−0.396，P=.003）的唯一预测因素。AL 与 FAZ 面积、大血管直径或盘区任何位置的血管密度均无相关性。年龄是视乳头头部 PD（=−0.287，P=.024）和 VLD（=−0.289，P=.023）的唯一预测因素。AL 与浅层黄斑旁微血管呈负相关，但与视乳头周围毛细血管无相关性，提示随着 AL 的增加，视盘末端的内视网膜伸展更多。
