Drug Clinical Trial Institutions, Guangzhou Twelfth People's Hospital, Guangzhou, China.
Pharmaceutical Department, Guangzhou Twelfth People's Hospital, Guangzhou, China.
BMC Cardiovasc Disord. 2024 Oct 22;24(1):584. doi: 10.1186/s12872-024-04259-2.
A high body mass index (hBMI) is one of the major risk factors for ischemic stroke (IS), although independent estimates of the global burden and trend of IS attributable to hBMI are unclear.
Study data were extracted from the Global Burden of Diseases, Injuries, and Risk Factors Study and analysed by age, sex, year, and geographical location. The sociodemographic index (SDI) and the human development index (HDI) were used as indicators of national socioeconomic status. Geographic distributions and trends were assessed by calculating the estimated annual percentage change (EAPC). Associations between the age-standardized death rate (ASMR) or disability-adjusted life year rate (DALY) and socioeconomic status were analysed.
Deaths and DALYs increased worldwide from 1990-2021, with increases of 95.74% for the former and 133.00% for the latter; the ASMR and ASDR decreased, with an ASMR and ASDR-related EAPCs of -1.10 (95% CI: -1.24--0.96) and 0.04 (95% CI:-0.47-0.55), respectively; women had greater numbers of deaths and DALYs, and the majority of deaths and DALYs were shared by those aged ≥ 70. The highest burden rates were shared by Eastern Europe, North Africa, the Middle East, and Central Asia. The ASMR-related EAPCs were associated with the ASMR in 1990 (R = -0.35, P < 0.001) and the SDI in 2021 in different countries (R = -0.66, P < 0.001); these patterns were similar to those of the ASDR; the HDI in 2021 was associated with the ASMR-related EAPC (R = -0.71, P < 0.001) and the ASDR-related EAPC in different countries (R = -0.71, P < 0.001).
The number of deaths and DALYs from ischemic stroke attributable to hBMI worldwide increased substantially from 1990-2021. Successful population-wide initiatives targeting hBMI may mitigate a wide range of burdens on this disease. Taking into account variations in the SDI burden, future prevention and control strategies must be developed and implemented according to country-specific development status.
高身体质量指数（hBMI）是缺血性中风（IS）的主要危险因素之一，尽管独立估计 hBMI 导致的全球 IS 负担和趋势尚不清楚。
研究数据取自全球疾病、伤害和危险因素研究，并按年龄、性别、年份和地理位置进行分析。社会人口指数（SDI）和人类发展指数（HDI）被用作国家社会经济地位的指标。通过计算估计的年变化百分比（EAPC）评估地理分布和趋势。通过分析年龄标准化死亡率（ASMR）或伤残调整生命年率（DALY）与社会经济地位之间的关系来评估关联。
1990 年至 2021 年，全球死亡人数和 DALY 增加，前者增加了 95.74%，后者增加了 133.00%；ASMR 和 ASDR 下降，ASMR 和 ASDR 相关的 EAPC 分别为-1.10（95%CI：-1.24-0.96）和 0.04（95%CI：-0.47-0.55）；女性死亡人数和 DALY 较多，大多数死亡和 DALY 发生在年龄≥70 岁的人群中。东欧、北非、中东和中亚的负担率最高。1990 年 ASMR 相关的 EAPC 与各国的 ASMR（R=−0.35，P<0.001）和 2021 年的 SDI 相关（R=−0.66，P<0.001）呈负相关；ASDR 模式相似；2021 年的 HDI 与 ASMR 相关的 EAPC（R=−0.71，P<0.001）和各国的 ASDR 相关的 EAPC（R=−0.71，P<0.001）呈负相关。
1990-2021 年，全球归因于 hBMI 的缺血性中风死亡人数和 DALY 大幅增加。针对 hBMI 的全人群成功举措可能会减轻这种疾病的广泛负担。考虑到 SDI 负担的差异，未来必须根据各国的发展状况制定和实施预防和控制策略。
