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一组自闭症儿童的脑电图特征、适应性特征及临床表型研究——一项初步研究

Investigation of Electroencephalographic Aspects, Adaptive Features, and Clinical Phenotypes in a Group of Children with Autism-A Pilot Study.

作者信息

Capisizu Alexandru, Zăgrean Leon, Poenaru Elena, Tudorache Elena, Bulf Mihaela Anca, Capisizu Adriana Sorina

机构信息

Dr. Constantin Gorgos Psychiatry Hospital, 030442 Bucharest, Romania.

Division of Physiology and Neuroscience, Department of Functional Sciences, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.

出版信息

Clin Pract. 2025 Feb 27;15(3):50. doi: 10.3390/clinpract15030050.

Abstract

(1) Background: Autism, as an important global problem that affects many phenotypically different individuals, is associated with electroencephalographic (EEG) abnormalities and adaptability impairment. (2) Materials and Methods: In this retrospective study of a group of 101 autistic children, we aimed to evaluate the presence of EEG abnormalities, adaptive features, and clinical phenotypes via EEG, the Adaptive Behavior Assessment System II (ABAS II) scale, and neurological examination. (3) Results: Our results showed statistically significant associations between the level of adaptability obtained through the ABAS II scale and neurological deficit, specifically in terms of coordination impairment. There were also statistically significant differences between the level of adaptability and clinical phenotypes between autism type groups. (4) Conclusions: This study shows that children with autism are likely to exhibit neurological and adaptive abnormalities. Non-invasive assessment tools, such as EEG recordings, the ABAS II scale, and neurological examination offer valuable support for improved diagnosis and management.

摘要

(1) 背景:自闭症是一个影响众多表型各异个体的重要全球性问题,与脑电图(EEG)异常及适应性损害相关。(2) 材料与方法:在这项对101名自闭症儿童的回顾性研究中,我们旨在通过脑电图、适应性行为评估系统II(ABAS II)量表和神经学检查来评估EEG异常、适应性特征及临床表型的存在情况。(3) 结果:我们的结果显示,通过ABAS II量表获得的适应性水平与神经功能缺损之间存在统计学上的显著关联,特别是在协调功能损害方面。自闭症类型组之间的适应性水平和临床表型也存在统计学上的显著差异。(4) 结论:本研究表明,自闭症儿童可能表现出神经学和适应性异常。脑电图记录、ABAS II量表和神经学检查等非侵入性评估工具为改善诊断和管理提供了有价值的支持。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b9/11941036/9329a7c50777/clinpract-15-00050-g001.jpg

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