Son Jeongmin, Heo Chan, Kim Hyeongyu, Meyyappan M, Kim Kihyun
Division of Electronics and Information Engineering, Jeonbuk National University, Jeonju 54896, Republic of Korea.
Centre for Nanotechnology, Indian Institute of Technology Guwahati, Guwahati 781039, India.
Biosensors (Basel). 2025 Feb 22;15(3):135. doi: 10.3390/bios15030135.
Biologically sensitive field-effect transistors (BioFETs) have advanced the biosensing capabilities in various fields such as healthcare, security and environmental monitoring. Here, we propose a junctionless BioFET (JL-BioFET) for the high-sensitivity and low-cost detection of biomolecules and analyze it using detailed device simulations. In contrast to the conventional FET with junctions, the JL-BioFET simplifies fabrication by doping the source, channel and drain simultaneously with the same types of impurities, thereby reducing the fabrication effort and cost. Additionally, if the device is designed with optimal bias, it can operate with only the source and drain terminals, which reduces power consumption. Thus, cost reduction and reduced power consumption are strong motivations to pursue a new design. Therefore, we simulated two JL-BioFET structures (SOI JL, bulk JL) that operate without a gate electrode and compared their biosensing performances. The bulk JL-BioFET showed an average sensitivity three times higher than that of the SOI JL-BioFET across varying charge levels. Then, we optimized the sensing performance of the bulk JL-BioFET by adjusting three key parameters: the active layer thickness and the doping concentrations of the active layer and substrate. These encouraging results are expected to lead to future fabrication efforts to realize bulk JL-BioFETs for high-performance biosensing.
生物敏感场效应晶体管(BioFET)提升了医疗保健、安全和环境监测等各个领域的生物传感能力。在此,我们提出一种用于高灵敏度、低成本生物分子检测的无结BioFET(JL - BioFET),并使用详细的器件模拟对其进行分析。与传统的有结场效应晶体管不同,JL - BioFET通过用相同类型的杂质同时对源极、沟道和漏极进行掺杂来简化制造过程,从而减少制造工作量和成本。此外,如果器件设计有最佳偏置,它可以仅通过源极和漏极端子运行,这降低了功耗。因此,降低成本和降低功耗是追求新设计的强大动力。所以,我们模拟了两种无需栅电极运行的JL - BioFET结构(绝缘体上硅JL、体硅JL),并比较了它们的生物传感性能。在不同电荷水平下,体硅JL - BioFET的平均灵敏度比绝缘体上硅JL - BioFET高两倍。然后,我们通过调整三个关键参数:有源层厚度以及有源层和衬底的掺杂浓度,优化了体硅JL - BioFET的传感性能。这些令人鼓舞的结果有望推动未来的制造工作,以实现用于高性能生物传感的体硅JL - BioFET。