Beck Anna, Uhrig Michael, Schuster Alexander, Korb Christina, Pfeiffer Norbert, Lorenz Katrin
Department of Ophthalmology, University Medical Center, Johannes Gutenberg-University, 55131 Mainz, Germany.
J Clin Med. 2025 Mar 19;14(6):2112. doi: 10.3390/jcm14062112.
: In glaucoma patients, the fluctuation in intraocular pressure during the day seems to have an influence on the progression of the disease. The contact lens sensor (CLS) Triggerfish from the company SENSIMED records ocular dimensional changes for 24 h. The aim was to determine the amplitude of the measurements with a contact lens sensor before and after trabeculectomy (TE) in glaucoma patients. : Twelve patients with glaucoma were included in this prospective, single-arm, single-center, interventional study. All patients received a CLS measurement for 24 h 8 ± 2 days before and 12 weeks (±1 week) after surgery. The raw data of the measurements were modeled using a double-harmonic cosine function. Fluctuation in the raw CLS data, amplitude, and the MESOR (midline estimating statistic of rhythm, rhythm-adjusted mean) of the modeled data were investigated. The safety and feasibility of the CLS measurements were evaluated. : Nine patients underwent the complete 24-h wearing period before and after surgery. Whereas the MESOR changed significantly before and after surgery ( = 0.04), the amplitude of the modeled data did not change significantly and the daytime fluctuation and circadian rhythm also did not vary significantly. The CLS could be safely removed from all study eyes after surgery. : The non-significant change in amplitude suggests that diurnal fluctuations persist after TE. This contrasts with reports in the literature that show that TE reduces diurnal fluctuations. It can be assumed that the significant reduction in the MESOR represents the reduction in the average intraocular pressure over 24 h. The CLS can be used safely three months after TE.
在青光眼患者中，白天眼压的波动似乎对疾病进展有影响。SENSIMED公司的隐形眼镜传感器（CLS）Triggerfish可记录24小时的眼部尺寸变化。目的是确定青光眼患者小梁切除术（TE）前后使用隐形眼镜传感器测量的幅度。12例青光眼患者纳入这项前瞻性、单臂、单中心干预性研究。所有患者在手术前8±2天和手术后12周（±1周）接受24小时的CLS测量。测量的原始数据使用双谐波余弦函数进行建模。研究了CLS原始数据的波动、幅度以及建模数据的MESOR（节律中线估计统计量，节律调整均值）。评估了CLS测量的安全性和可行性。9例患者在手术前后都经历了完整的24小时佩戴期。虽然手术前后MESOR有显著变化（P = 0.04），但建模数据的幅度没有显著变化，白天波动和昼夜节律也没有显著变化。手术后可以安全地从所有研究眼中取出CLS。幅度无显著变化表明小梁切除术后昼夜波动仍然存在。这与文献报道的小梁切除术可减少昼夜波动形成对比。可以认为MESOR的显著降低代表24小时内平均眼压的降低。小梁切除术后三个月可以安全使用CLS。
