Wissing M C, van der Wal S E I, Bongarts S, Aarnink J, Notten K J B, van Kuijk S M J, Dam A H D M, Vissers K C P, Kluivers K B, van Alfen N
Department of Obstetrics and Gynaecology, Radboud University Medical Center, Nijmegen, The Netherlands.
Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Pain Pract. 2025 Apr;25(4):e70028. doi: 10.1111/papr.70028.
Chronic pelvic pain syndrome (CPPS) is pain in the region of the lower pelvis for three months or longer. Which is often accompanied by complaints of organ systems in the lower abdomen. CPPS is often a subjective diagnosis where electrodiagnostic tests are recommended as a supplement in defining a diagnosis.
Synthesize the clinical studies that describe electrodiagnostic testing in humans with a clinical diagnosis of CPPS.
Registered in PROSPERO (CRD42024510404). A systematic search in Medline/PubMed, Embase, CINAHL, and Web of science, from inception till February 2024, complemented with reference examining. Two reviewers independently reviewed titles, abstracts, and full-text papers, and performed data extraction. Reviews were excluded, and papers were included if patients were clinically diagnosed with CPPS and underwent EMG and/or SSEP. The QUADAS-2 tool was used to assess the quality of studies.
Fourteen papers were included concerning EMG and/or SSEP, nine papers reported on EMG and five on SSEP. In total, 432 patients clinically diagnosed with CPPS underwent electrodiagnostic testing. 152/277 patients showed abnormalities on EMG and 102/155 patients had abnormal findings on SSEP. Due to the lack of quantitative data, no meta-analysis could be performed.
Abnormalities on electrodiagnostic testing are seen in half of the patients with CPPS, and therefore not recommended as a substitute in the diagnostic process. The low number of patients enrolled in this review needs to be taken into consideration when interpreting the results. Further research on the sensitivity of EMG and/or SSEP in PN is recommended.
慢性盆腔疼痛综合征（CPPS）是指下腹部骨盆区域疼痛持续三个月或更长时间，常伴有下腹部器官系统的不适主诉。CPPS通常是一种主观诊断，推荐进行电诊断测试作为辅助诊断手段。
综合描述临床诊断为CPPS的患者进行电诊断测试的临床研究。
在PROSPERO（CRD42024510404）注册。对Medline/PubMed、Embase、CINAHL和Web of science进行系统检索，检索时间从建库至2024年2月，并辅以参考文献审查。两名审阅者独立审阅标题、摘要和全文论文，并进行数据提取。排除综述，纳入临床诊断为CPPS且接受肌电图（EMG）和/或躯体感觉诱发电位（SSEP）检查的患者的论文。使用QUADAS-2工具评估研究质量。
纳入14篇关于EMG和/或SSEP的论文，9篇报告了EMG，5篇报告了SSEP。共有432例临床诊断为CPPS的患者接受了电诊断测试。152/277例患者EMG异常，102/155例患者SSEP检查结果异常。由于缺乏定量数据，无法进行荟萃分析。
一半的CPPS患者电诊断测试结果异常，因此不建议将其作为诊断过程中的替代方法。解释结果时需要考虑本综述纳入患者数量较少这一情况。建议进一步研究EMG和/或SSEP在阴部神经（PN）中的敏感性。
