Iwama Seitaro, Ueno Takamasa, Fujimaki Tatsuro, Ushiba Junichi
Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Yokohama, Kanagawa, Japan.
Graduate School of Science and Technology, Keio University, Yokohama, Kanagawa, Japan.
iScience. 2025 Mar 3;28(4):112145. doi: 10.1016/j.isci.2025.112145. eCollection 2025 Apr 18.
Motor performance improvement through self-modulation of brain activity has been demonstrated through neurofeedback. However, the sensorimotor plasticity induced through the training remains unclear. Here, we combined individually tailored closed-loop neurofeedback, neurophysiology, and behavioral assessment to characterize how the training can modulate the somatosensory system and improve performance. The real-time neurofeedback of human electroencephalogram (EEG) signals enhanced participants' self-modulation ability of intrinsic neural oscillations in the primary somatosensory cortex (S1) within 30 min. Further, the short-term reorganization in S1 was corroborated by the post-training changes in somatosensory evoked potential (SEP) amplitude of the early component from S1. Meanwhile those derived from peripheral and spinal sensory fibers were maintained (N9 and N13 components), suggesting that the training manipulated S1 activities. Behavioral evaluation demonstrated improved performance during keyboard touch-typing indexed by resolved speed-accuracy trade-off. Collectively, our results provide evidence that neurofeedback training induces functional reorganization of S1 and sensorimotor function.
通过神经反馈已证明，通过大脑活动的自我调节可改善运动表现。然而，训练所诱导的感觉运动可塑性仍不清楚。在此，我们结合个性化定制的闭环神经反馈、神经生理学和行为评估，以表征训练如何调节体感系统并改善表现。人类脑电图（EEG）信号的实时神经反馈在30分钟内增强了参与者对初级体感皮层（S1）内在神经振荡的自我调节能力。此外，S1的短期重组通过训练后S1早期成分体感诱发电位（SEP）振幅的变化得到证实。同时，来自外周和脊髓感觉纤维的那些成分（N9和N13成分）保持不变，表明训练操控了S1的活动。行为评估表明，在键盘触摸打字过程中，以解决速度 - 准确性权衡为指标的表现有所改善。总体而言，我们的结果提供了证据，证明神经反馈训练可诱导S1的功能重组和感觉运动功能。
