Ithurbide Solenne, Buan Nicole, Schulze Stefan
Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC, Canada.
Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE, USA.
Commun Biol. 2025 Mar 29;8(1):519. doi: 10.1038/s42003-025-07962-8.
Over the last two decades archaeal research has expanded into a wide-ranging research field, driven by a fairly small research community. Archaea are now recognized as important players in the One-Health approach and expertise on the biology of archaea has become crucial in the study of a broad range of topics and environments, including the host-associated microbiomes, major nutrient cycles, greenhouse gas metabolism, the cell biology and origin of eukaryotes, adaptation of life to extremes, as well as various biotechnological applications. Here, we summarize existing resources and ongoing efforts in the engaged broader archaeal scientific community to accelerate research and resource sharing guided by FAIR (findable, accessible, interoperable, reusable) data-sharing principles. We highlight ongoing community efforts that: (i) aim to share protocols and best practices for working with archaea (e.g. ARCHAEA.bio), (ii) combine large 'omics datasets for the dissemination of unified, system-wide results (e.g. Archaeal Proteome Project, KBase) and (iii) provide opportunities for scientists to present their work in a supportive environment and to forge connections and collaborations (e.g. Archaea Power Hour). Together, these resources and projects promise to spur and cross-fertilize research, making archaeal research more accessible to a broader and more diverse audience.
在过去二十年中，古菌研究已扩展成为一个广泛的研究领域，推动这一领域发展的是一个规模相对较小的研究群体。如今，古菌被视为“同一健康”方法中的重要角色，古菌生物学方面的专业知识对于研究广泛的主题和环境至关重要，这些主题和环境包括与宿主相关的微生物群、主要营养循环、温室气体代谢、真核生物的细胞生物学和起源、生命对极端环境的适应，以及各种生物技术应用。在此，我们总结了活跃的更广泛古菌科学界现有的资源和正在进行的工作，以在“可发现、可访问、可互操作、可重用”（FAIR）数据共享原则的指导下加速研究和资源共享。我们重点介绍了正在进行的社区工作，这些工作：（i）旨在分享与古菌研究相关的实验方案和最佳实践（例如ARCHAEA.bio），（ii）整合大型“组学”数据集以传播统一的全系统结果（例如古菌蛋白质组计划、KBase），以及（iii）为科学家提供在支持性环境中展示其工作并建立联系与合作的机会（例如古菌力量时刻）。总之，这些资源和项目有望促进研究并实现交叉融合，使更广泛和更多样化的受众更容易接触到古菌研究。
