Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi, Telangana, 502285, India.
Department of Pharmaceutics and Pharmaceutical Technology, L M College of Pharmacy, Ahmedabad, 380009, India.
Small. 2024 Aug;20(35):e2401631. doi: 10.1002/smll.202401631. Epub 2024 May 1.
Cancer nanovaccines represent a promising frontier in cancer immunotherapy, utilizing nanotechnology to augment traditional vaccine efficacy. This review comprehensively examines the current state-of-the-art in cancer nanovaccine development, elucidating innovative strategies and technologies employed in their design. It explores both preclinical and clinical advancements, emphasizing key studies demonstrating their potential to elicit robust anti-tumor immune responses. The study encompasses various facets, including integrating biomaterial-based nanocarriers for antigen delivery, adjuvant selection, and the impact of nanoscale properties on vaccine performance. Detailed insights into the complex interplay between the tumor microenvironment and nanovaccine responses are provided, highlighting challenges and opportunities in optimizing therapeutic outcomes. Additionally, the study presents a thorough analysis of ongoing clinical trials, presenting a snapshot of the current clinical landscape. By curating the latest scientific findings and clinical developments, this study aims to serve as a comprehensive resource for researchers and clinicians engaged in advancing cancer immunotherapy. Integrating nanotechnology into vaccine design holds immense promise for revolutionizing cancer treatment paradigms, and this review provides a timely update on the evolving landscape of cancer nanovaccines.
癌症纳米疫苗代表了癌症免疫治疗的一个有前途的前沿领域，利用纳米技术增强传统疫苗的疗效。本综述全面考察了癌症纳米疫苗开发的最新进展，阐明了其设计中采用的创新策略和技术。它探讨了临床前和临床进展，强调了关键研究，这些研究证明了它们引发强大抗肿瘤免疫反应的潜力。该研究涵盖了多个方面，包括基于生物材料的纳米载体用于抗原传递、佐剂选择以及纳米级特性对疫苗性能的影响。深入了解肿瘤微环境与纳米疫苗反应之间的复杂相互作用，突出了优化治疗效果的挑战和机遇。此外，该研究还对正在进行的临床试验进行了全面分析，呈现了当前临床领域的一个快照。通过整理最新的科学发现和临床进展，本研究旨在为从事癌症免疫治疗的研究人员和临床医生提供一个全面的资源。将纳米技术整合到疫苗设计中为彻底改变癌症治疗范式带来了巨大的希望，本综述及时更新了癌症纳米疫苗不断发展的领域。
