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1
Marked enhancement in vivo of adjuvant activity of muramyl dipeptide to protein antigens and to synthetic weak immunogens with monoclonal anti-muramyl dipeptide antibodies.用单克隆抗胞壁酰二肽抗体在体内显著增强胞壁酰二肽对蛋白质抗原和合成弱免疫原的佐剂活性。
Infect Immun. 1985 Aug;49(2):312-9. doi: 10.1128/iai.49.2.312-319.1985.
2
Marked enhancement of macrophage activation induced by synthetic muramyl dipeptide (MDP) conjugate using monoclonal anti-MDP antibodies.使用单克隆抗Muramyl二肽（MDP）抗体对合成Muramyl二肽（MDP）偶联物诱导的巨噬细胞活化有显著增强作用。
Cell Immunol. 1984 Jul;86(2):269-77. doi: 10.1016/0008-8749(84)90381-2.
3
Immunoadjuvant effects of the synthetic muramyl-dipeptide (MDP) N-acetylmuramyl-L-alanyl-D-isoglutamine.合成的胞壁酰二肽（MDP）N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺的免疫佐剂作用。
Z Immunitatsforsch Immunobiol. 1978 Oct;155(1):87-92.
4
Preparation for hapten help by glucan, muramyl dipeptide, and its L-ala-Glycerol-mycolate derivative.通过葡聚糖、胞壁酰二肽及其L-丙氨酰-甘油-霉菌酸酯衍生物进行半抗原的制备辅助。
J Leukoc Biol. 1985 Aug;38(2):317-25. doi: 10.1002/jlb.38.2.317.
5
Effect of a synthetic adjuvant on the induction of primary immune responses in T cell-depleted spleen cultures.一种合成佐剂对T细胞缺失脾脏培养物中初次免疫应答诱导的影响。
J Immunol. 1978 Jul;121(1):383-9.
6
The muramyl dipeptide analog GMTP-N-DPG preferentially induces cellular immunity to soluble antigens.
Vaccine. 1997 Nov;15(16):1748-52. doi: 10.1016/s0264-410x(97)00110-2.
7
Study of immunomodulatory properties of N-acetylmuramyl-L-alanyl-D-isoglutamine and N-acetylglucosaminyl-(beta 1----4)-N-acetylmuramyl-L-alanyl-D-isoglutamine.N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺和N-乙酰葡糖胺基-(β1→4)-N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺的免疫调节特性研究
Biomed Sci. 1991;2(6):651-8.
8
Detection of antibodies to muramyl dipeptide, the adjuvant moiety of streptococcal cell wall, in patients with rheumatic fever.风湿热患者中针对链球菌细胞壁佐剂部分——胞壁酰二肽抗体的检测。
J Infect Dis. 1986 Dec;154(6):1012-7. doi: 10.1093/infdis/154.6.1012.
9
Effects of muramyl dipeptide treatment on resistance to infection with Toxoplasma gondii in mice.胞壁酰二肽处理对小鼠抗弓形虫感染能力的影响。
Infect Immun. 1981 Feb;31(2):716-22. doi: 10.1128/iai.31.2.716-722.1981.
10
Enhancement by murabutide of the immune response to natural and synthetic hepatitis B surface antigens.莫拉司亭对天然和合成乙肝表面抗原免疫反应的增强作用。
Infect Immun. 1984 Jul;45(1):261-6. doi: 10.1128/iai.45.1.261-266.1984.

引用本文的文献

1
Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activation.真核生物起始因子5A是人类免疫缺陷病毒1型Rev激活结构域介导反式激活的细胞靶点。
J Cell Biol. 1993 Dec;123(6 Pt 1):1309-20. doi: 10.1083/jcb.123.6.1309.

本文引用的文献

1
Spectrometric evaluation of the approximate pK of the carboxyl group in 2,4-dinitrophenyl-amino acids.2,4-二硝基苯基氨基酸中羧基近似pK值的光谱测定评估
Biochemistry. 1962 Jan;1:75-8. doi: 10.1021/bi00907a012.
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A modified colorimetric method for the estimation of N-acetylamino sugars.一种用于估算N-乙酰氨基糖的改良比色法。
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In vitro activation of tumoricidal properties in rat alveolar macrophages by synthetic muramyl dipeptide encapsulated in liposomes.脂质体包裹的合成型胞壁酰二肽对大鼠肺泡巨噬细胞杀肿瘤特性的体外激活作用
Cell Immunol. 1981 Jan 1;57(1):42-50. doi: 10.1016/0008-8749(81)90118-0.
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Generation of hybridomas secreting murine reaginic antibodies of anti-DNP specificity.分泌抗二硝基苯特异性鼠反应素抗体的杂交瘤的产生。
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Analysis of the antigenic relationship of various derivatives of n-acetyl-muramyl-l-ala-d-isoglutamine (MDP), using anti-MDP antibodies.使用抗MDP抗体分析N-乙酰-胞壁酰-L-丙氨酰-D-异谷氨酰胺（MDP）各种衍生物的抗原关系。
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Muramyl peptides. Chemical structure, biological activity and mechanism of action.胞壁酰肽。化学结构、生物活性及作用机制。
Mol Cell Biochem. 1981 Dec 4;41:27-47. doi: 10.1007/BF00225295.
7
Successful immunization with a totally synthetic diphtheria vaccine.用完全合成的白喉疫苗成功免疫。
Proc Natl Acad Sci U S A. 1982 Aug;79(16):5042-6. doi: 10.1073/pnas.79.16.5042.
8
Monoclonal antibodies to the synthetic adjuvant muramyl dipeptide: characterization of the specificity.针对合成佐剂胞壁酰二肽的单克隆抗体：特异性表征
Mol Immunol. 1983 Jul;20(7):745-52. doi: 10.1016/0161-5890(83)90052-4.
9
Specific monoclonal IgM is a potent adjuvant in murine malaria vaccination.特异性单克隆IgM在鼠疟疫苗接种中是一种有效的佐剂。
Nature. 1983;302(5905):256-8. doi: 10.1038/302256a0.
10
Immunological castration of male mice by a totally synthetic vaccine administered in saline.通过在盐水中注射完全合成疫苗对雄性小鼠进行免疫去势。
Proc Natl Acad Sci U S A. 1982 Sep;79(17):5392-5. doi: 10.1073/pnas.79.17.5392.

用单克隆抗胞壁酰二肽抗体在体内显著增强胞壁酰二肽对蛋白质抗原和合成弱免疫原的佐剂活性。

Marked enhancement in vivo of adjuvant activity of muramyl dipeptide to protein antigens and to synthetic weak immunogens with monoclonal anti-muramyl dipeptide antibodies.

作者信息

Bahr G M, Tello D S, Chedid L A

出版信息

Infect Immun. 1985 Aug;49(2):312-9. doi: 10.1128/iai.49.2.312-319.1985.

DOI:10.1128/iai.49.2.312-319.1985
PMID:4018873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC262016/
Abstract

Priming of mice with complexes of antigen coupled to muramyl dipeptide and monoclonal anti-muramyl dipeptide antibodies enhanced the adjuvant activity of muramyl dipeptide on the humoral response to the antigen. The enhancement did not occur with free (uncoupled) muramyl dipeptide and required the presence of an adjuvant-active hapten within the complex as well as the Fc fragment of the monoclonal antibody. This system proved highly effective in eliciting antibodies to synthetic weak immunogens whereas muramyl dipeptide, on its own, exerts very little or no adjuvant activity. The effect was not due to a general polyclonal activation and was restricted to the antigen coupled to the synthetic adjuvant. Possible pathways involved in this phenomenon are discussed.

摘要

用与胞壁酰二肽偶联的抗原复合物和单克隆抗胞壁酰二肽抗体对小鼠进行预处理，可增强胞壁酰二肽对该抗原体液反应的佐剂活性。游离（未偶联）的胞壁酰二肽不会出现这种增强作用，且该复合物中需要存在具有佐剂活性的半抗原以及单克隆抗体的Fc片段。该系统在引发针对合成弱免疫原的抗体方面被证明非常有效，而胞壁酰二肽本身的佐剂活性很小或没有。这种效应并非由于一般的多克隆激活，且仅限于与合成佐剂偶联的抗原。文中讨论了参与这一现象的可能途径。