Su Luyang, Ren Yanan, Xu Ren, Zhao Shixia, Liu Weilan, Meng Cuiqiao, Zhou Xuan, Du Zeqing
Physical Examination Center, Hebei General Hospital, Shijiazhuang, Hebei, China.
Department of Obstetrics and Gynecology, Hebei General Hospital, Shijiazhuang, Hebei, China.
Front Public Health. 2025 Mar 24;13:1525986. doi: 10.3389/fpubh.2025.1525986. eCollection 2025.
Endometriosis affects up to 15% of women of reproductive age and can lead to various symptoms. More than 200 million people worldwide are at risk of higher than safe levels of arsenic exposure through drinking water. Studies investigating the relationship between arsenic and endometriosis are very limited and have yielded inconsistent results. This study aimed to explore the relationship between total urinary arsenic, arsenic species (Urinary arsenous acid, Urinary Arsenic acid, Urinary Arsenobetaine, Urinary Arsenocholine, Urinary Dimethylarsinic acid, Urinary Monomethylarsonic acid) and endometriosis.
We utilized a nationally representative dataset from the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2006. A total of 650 participants were included. We examined the association between total urinary arsenic and different arsenic species with endometriosis using weighted multivariate logistic regression models.
Urinary arsenous acid and urinary monomethylarsonic acid (MMA) were positively correlated with endometriosis ( < 0.05). After adjusting for potential confounding factors, the positive correlation of urinary MMA remained significant (OR: 1.317, 95%CI: 1.074-1.615). Subgroup analyses and interaction tests indicated that this association was not dependent.
Our research underscores a significant positive association observed between factors urinary MMA and endometriosis. Future research is needed to elucidate the specific mechanisms behind this association.
子宫内膜异位症影响着高达15%的育龄女性，并可导致多种症状。全球超过2亿人面临因饮用水中砷暴露水平高于安全标准而带来的风险。调查砷与子宫内膜异位症之间关系的研究非常有限，且结果并不一致。本研究旨在探讨尿总砷、砷形态（尿亚砷酸、尿砷酸、尿砷甜菜碱、尿砷胆碱、尿二甲基砷酸、尿一甲基砷酸）与子宫内膜异位症之间的关系。
我们使用了来自2003年至2006年美国国家健康与营养检查调查（NHANES）的具有全国代表性的数据集。总共纳入了650名参与者。我们使用加权多变量逻辑回归模型研究了尿总砷和不同砷形态与子宫内膜异位症之间的关联。
尿亚砷酸和尿一甲基砷酸（MMA）与子宫内膜异位症呈正相关（<0.05）。在调整潜在混杂因素后，尿MMA的正相关性仍然显著（OR：1.317，95%CI：1.074 - 1.615）。亚组分析和交互作用检验表明这种关联并不具有依赖性。
我们的研究强调了尿MMA与子宫内膜异位症之间存在显著的正相关。未来需要进一步研究以阐明这种关联背后的具体机制。
