Cunha Ana Paula da, Mota Jurema Corrêa da, Cruz Marly Marques da, Miranda Raquel, Rosso Liza, Kruppa Mariele, Santos Juliane, Silva Andreia Souza Pinto da, Faccin Giordana, Schweitzer Caroline, Zonta Ronaldo, Cota Vanda Lúcia
Fundação Oswaldo Cruz, Sergio Arouca National School of Public Health - Rio de Janeiro (RJ), Brazil.
Fundação Oswaldo Cruz, Institute of Scientific and Technological Communication and Information on Health - Rio de Janeiro (RJ), Brazil.
Rev Bras Epidemiol. 2025 Apr 7;28:e250015. doi: 10.1590/1980-549720250015. eCollection 2025.
To analyze the factors associated with antiretroviral therapy interruption among people living with the human immunodeficiency virus participating in the A Hora é Agora [The Time is Now] project in the municipalities of Campo Grande, Curitiba, and Florianópolis.
This is a cross-sectional analytical study using data from the Brazilian Medication Logistics Control System, collected between October 2019 and September 2022. Bivariate analyses were performed to assess associations between sex, age group, race/skin color, and level of education, with the outcomes of treatment interruption and the number of times the treatment was interrupted, using the χ2 test with a 5% significance level.
In Campo Grande, treatment interruption was more frequent among individuals with eight to 11 years of formal education (34.0%). In Curitiba, women (20.4%) showed a higher frequency of treatment interruption, and the age group of 50 years or older had a higher likelihood of treatment interruption (OR: 1.73; 95%CI: 1.12-2.66). In Florianópolis, 31.1% of women experienced treatment interruption, and individuals with up to seven years of formal education had a higher likelihood of treatment interruption (OR: 1.62; 95%CI: 1.15-2.29).
The interruption of antiretroviral therapy was significantly associated with sex, level of education, and age group, with distinct patterns across the analyzed territorial contexts. These findings highlight the need for targeted interventions aimed at vulnerable groups, considering regional differences and local challenges to improve treatment adherence.
分析参与大坎普市、库里蒂巴市和弗洛里亚诺波利斯市“就是现在”项目的人类免疫缺陷病毒感染者中与抗逆转录病毒治疗中断相关的因素。
这是一项横断面分析研究，使用了2019年10月至2022年9月期间从巴西药品物流控制系统收集的数据。进行双变量分析，以评估性别、年龄组、种族/肤色和教育程度与治疗中断结果以及治疗中断次数之间的关联，使用显著性水平为5%的χ2检验。
在大坎普市，接受过8至11年正规教育的个体治疗中断更为频繁（34.0%）。在库里蒂巴市，女性（20.4%）的治疗中断频率更高，50岁及以上年龄组的治疗中断可能性更大（比值比：1.73；95%置信区间：1.12 - 2.66）。在弗洛里亚诺波利斯市，31.1%的女性经历过治疗中断，接受正规教育年限最多为7年的个体治疗中断可能性更大（比值比：1.62；95%置信区间：1.15 - 2.29）。
抗逆转录病毒治疗的中断与性别、教育程度和年龄组显著相关，在所分析的不同地区背景下存在不同模式。这些发现凸显了针对弱势群体开展有针对性干预措施的必要性，要考虑到地区差异和当地挑战以提高治疗依从性。
