Lin Xuling, Lam Mei Lyn Carissa, Chuang Ding Fang, Yuen Joanne Yong Ern, Fu Liqing, Jun Zhi Teh Valerie, Marliya Aynul, Saffari Seyed Ehsan, Lim Christen Sheng Jie, Wong Yu-Lin, Seet Ying Hao Christopher
Department of Neurology, National Neuroscience Institute, Singapore.
Department of Research, National Neuroscience Institute, Singapore.
Neurol Clin Pract. 2025 Apr;15(2):e200447. doi: 10.1212/CPJ.0000000000200447. Epub 2025 Feb 25.
Traditional lumbar punctures (LPs) often fail, leading to diagnostic delays and increased risks. Ultrasound guidance provides improved success rates but faces adoption barriers due to neuraxial-ultrasound training and implementation challenges. The Ultrasound-Guided Spinal Landmark Identification With Needle Navigation System and Position and Angular Marking System (uSINE-PAMS) were designed to address these issues: uSINE is a machine-learning software for neuraxial-ultrasound guidance; PAMS is a hardware that translates ultrasound data for accurate needle insertion.
A pilot study with 10 patients showed that uSINE-PAMS-guided LP achieved an 80% first-pass success rate with no complication; the median patient age was 43 years, and the median body mass index was 24.5 kg/m. The uSINE-PAMS system showed feasibility.
This pilot study showed that uSINE-PAMS-guided LP is feasible with a promising first-pass success rate at 80%. An ongoing phase 2 study (NCT05824546) of uSINE-PAMS may alter future standard of practice for LPs.
This pilot study is registered under ClinicalTrials.gov (ID: NCT05824546).
传统腰椎穿刺（LP）常常失败，导致诊断延迟和风险增加。超声引导可提高成功率，但由于神经轴超声培训和实施方面的挑战，其应用面临障碍。超声引导下脊柱地标识别与针导航系统及位置和角度标记系统（uSINE-PAMS）旨在解决这些问题：uSINE是一种用于神经轴超声引导的机器学习软件；PAMS是一种将超声数据转化以实现精确进针的硬件。
一项针对10名患者的试点研究表明，uSINE-PAMS引导下的LP首次穿刺成功率达到80%，且无并发症；患者年龄中位数为43岁，体重指数中位数为24.5kg/m²。uSINE-PAMS系统显示出可行性。
这项试点研究表明，uSINE-PAMS引导下的LP是可行的，首次穿刺成功率有望达到80%。正在进行的uSINE-PAMS 2期研究（NCT05824546）可能会改变未来LP的实践标准。
这项试点研究已在ClinicalTrials.gov（ID：NCT05824546）注册。
