Khan Anila, Ullah Shakeeb, Ramzan Faiqah, Rehman Ata Ur, Rehman Saifur, Kholik Kholik, Sukri Akhmad, Munawaroh Muhammad, Sucipto Teguh Hari
Institute of Biological Sciences, Gomal University, Dera Ismail Khan, Pakistan.
Faculty of Veterinary and Animal Sciences, Gomal University, Dera Ismail Khan, Pakistan.
Open Vet J. 2025 Feb;15(2):700-708. doi: 10.5455/OVJ.2025.v15.i2.18. Epub 2025 Feb 28.
Wound healing is a complex process involving inflammation, proliferation, and tissue remodeling. and vitamin E (Evion®) are well-known for their wound-healing properties because of their anti-inflammatory, antioxidant, and collagen-promoting effects.
This study aimed to evaluate the comparative efficacy of leaf extract, vitamin E, and their combined application on wound healing in rabbits ().
Twenty male rabbits were divided into four groups: control (treated with saline), , vitamin E, and combined ( + vitamin E). Full-thickness wounds were created on the dorsum of each rabbit, and treatments were applied daily for 14 days. Wound closure rates were measured on days 0, 4, 7, 10, and 14, followed by histopathological and biochemical analyses.
By day 14, the combined treatment group demonstrated the most significant wound closure, reducing the wound area by 75% compared with 50% in the group, 55% in the vitamin E group, and 35% in the control group. Histopathological analysis showed near-complete re-epithelialization, dense granulation tissue, and enhanced collagen deposition in the combined treatment group. The biochemical results indicated that the hydroxyproline levels were highest in the combined group (6.0 mg/g tissue) and that the antioxidant enzyme activity was elevated.
These findings suggest a synergistic effect between and vitamin E, leading to accelerated wound healing and improved tissue repair. The combination treatment has the potential to be a superior therapeutic approach for wound management.
伤口愈合是一个复杂的过程，涉及炎症、增殖和组织重塑。[物质名称]和维生素E（益寿亚®）因其抗炎、抗氧化和促进胶原蛋白生成的作用而以其伤口愈合特性而闻名。
本研究旨在评估[物质名称]叶提取物、维生素E及其联合应用对家兔伤口愈合的比较疗效。
将20只雄性家兔分为四组：对照组（用生理盐水处理）、[物质名称]组、维生素E组和联合组（[物质名称]+维生素E）。在每只家兔的背部制造全层伤口，并每天进行治疗，持续14天。在第0、4、7、10和14天测量伤口闭合率，随后进行组织病理学和生化分析。
到第14天，联合治疗组显示出最显著的伤口闭合，伤口面积减少了75%，相比之下，[物质名称]组为50%，维生素E组为55%，对照组为35%。组织病理学分析显示联合治疗组几乎完全重新上皮化、致密的肉芽组织和增强的胶原蛋白沉积。生化结果表明，联合组的羟脯氨酸水平最高（6.0毫克/克组织），抗氧化酶活性升高。
这些发现表明[物质名称]和维生素E之间存在协同作用，导致伤口愈合加速和组织修复改善。联合治疗有可能成为伤口管理的一种优越治疗方法。
