Heo Hye-Min, Lee Kyeong-Hwa, Heo Kyeong-Hwa, Hwang Ye-Chae, Lee Han-Gyul, Kwon Seungwon, Cho Seung-Yeon, Park Seong-Uk, Jung Woo-Sang, Moon Sang-Kwan, Ko Chang-Nam, Kim Hyug-Gi, Jahng Geon-Ho, Park Jung-Mi
Department of Cardiology and Neurology, Kyung Hee University College of Korean Medicine, Kyung Hee University Medical Center, Seoul, Republic of Korea.
Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
Brain Imaging Behav. 2025 Apr 11. doi: 10.1007/s11682-025-01004-x.
This study aimed to identify the clinical symptoms and indicators that might affect brain activity in patients with amnestic mild cognitive impairment. Thirty-one patients with amnestic mild cognitive impairment were recruited between March 2022 and June 2023. Functional magnetic resonance imaging, neuropsychological tests, and blood tests were also performed. Brain activation was analyzed using voxel- and region-of-interest-based methods. The correlation between the functional magnetic resonance imaging results and the acquired clinical indicators was determined using Pearson's correlation analysis. In the face-name association memory task, activation of the hippocampus and parahippocampal gyrus was found to be negatively correlated with the Short Form of the Geriatric Depression Scale score. Precentral gyrus and precuneus activation positively correlated with the percentage of correct answers in the one-back task. In the working memory N-back task, activation of the superior parietal lobule was positively correlated with the percentage of correct answers in the zero-back task. Age and activation in the hippocampus and parahippocampal gyrus are positively correlated. Depression, age, and sex significantly affected brain activity. Activation of the precentral gyrus, superior parietal lobule, and precuneus influences N-back task competency. Overall, this study is the first to analyze the correlation between brain function and clinical indicators of amnestic mild cognitive impairment.
本研究旨在确定可能影响遗忘型轻度认知障碍患者脑活动的临床症状和指标。在2022年3月至2023年6月期间招募了31例遗忘型轻度认知障碍患者。还进行了功能磁共振成像、神经心理学测试和血液检查。使用基于体素和感兴趣区域的方法分析脑激活情况。采用Pearson相关分析确定功能磁共振成像结果与所获取临床指标之间的相关性。在面孔-名字联想记忆任务中，发现海马体和海马旁回的激活与老年抑郁量表简表得分呈负相关。中央前回和楔前叶的激活与单回溯任务中的正确答案百分比呈正相关。在工作记忆N-回溯任务中，顶上小叶的激活与零回溯任务中的正确答案百分比呈正相关。年龄与海马体和海马旁回的激活呈正相关。抑郁、年龄和性别显著影响脑活动。中央前回、顶上小叶和楔前叶的激活影响N-回溯任务能力。总体而言，本研究首次分析了遗忘型轻度认知障碍的脑功能与临床指标之间的相关性。
