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泰国首例成功治疗猫感染病例报告。

First Case Report of Successful Treatment of Infection in a Cat in Thailand.

作者信息

Chuenngam Thapanee, Chermprapai Suttiwee

机构信息

Dermatology Center, Kasetsart University Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.

Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.

出版信息

Animals (Basel). 2025 Mar 23;15(7):925. doi: 10.3390/ani15070925.

DOI:10.3390/ani15070925
PMID:40218319
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11987839/
Abstract

A female domestic shorthair cat aged 2 years was referred with a 1-month history of subcutaneous nodules and multiple sites of draining tracts at the ventral abdomen. Initially, the cat was diagnosed with a fungal infection and treated with oral itraconazole, without improvement. Comprehensive diagnostics, including cytology, which indicated pyogranulomatous inflammation, fungal culture that was negative, and bacterial culture, confirmed the presence of . This infection was treated with a combination of oral azithromycin and topical amikacin based on susceptibility testing; later, doxycycline and an immunostimulant supplemented were combined at day 36 of treatment due to mild improvement of the lesions. The cat showed gradual improvement, achieving complete resolution of the lesions after 14 weeks, with no relapse noted 24 weeks post-treatment. This case report demonstrates the diagnostic challenges and the necessity for tailored, multi-drug therapeutic approaches in managing mycobacterial infections in cats. The findings may guide future treatments and raise awareness of mycobacterial diseases in cats.

摘要

一只2岁的雌性家养短毛猫因腹部腹侧有1个月的皮下结节病史和多处引流道而被转诊。最初,这只猫被诊断为真菌感染,并用口服伊曲康唑治疗,但没有改善。综合诊断,包括细胞学检查(提示脓性肉芽肿性炎症)、真菌培养(阴性)和细菌培养,证实了 的存在。根据药敏试验,该感染采用口服阿奇霉素和局部用阿米卡星联合治疗;后来,由于病变有轻度改善,在治疗第36天加用了强力霉素和免疫刺激剂。这只猫逐渐好转,14周后病变完全消退,治疗后24周未发现复发。本病例报告展示了诊断挑战以及在管理猫分枝杆菌感染时采用量身定制的多药治疗方法的必要性。这些发现可能会指导未来的治疗,并提高对猫分枝杆菌病的认识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d8d/11987839/5ffb278304d5/animals-15-00925-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d8d/11987839/7a407fd8d652/animals-15-00925-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d8d/11987839/0ca36ddb19f7/animals-15-00925-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d8d/11987839/c84b3ad9a0b1/animals-15-00925-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d8d/11987839/5ffb278304d5/animals-15-00925-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d8d/11987839/7a407fd8d652/animals-15-00925-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d8d/11987839/0ca36ddb19f7/animals-15-00925-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d8d/11987839/c84b3ad9a0b1/animals-15-00925-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d8d/11987839/5ffb278304d5/animals-15-00925-g004.jpg

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本文引用的文献

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Cutaneous Mycobacterioses of Cats and Dogs.猫和狗的皮肤分枝杆菌病
Vet Clin North Am Small Anim Pract. 2025 Mar;55(2):237-249. doi: 10.1016/j.cvsm.2024.11.009. Epub 2025 Jan 4.
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First report of complex () in a cat from Southeast Asia.东南亚一只猫身上发现复杂()的首例报告。 (注:原文括号处内容缺失,翻译可能不太完整准确)
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Bacterial species identification using MALDI-TOF mass spectrometry and machine learning techniques: A large-scale benchmarking study.
使用基质辅助激光解吸电离飞行时间质谱和机器学习技术进行细菌物种鉴定:一项大规模基准研究
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Actinic granuloma responding to doxycycline.对强力霉素有反应的光化性肉芽肿。
JAAD Case Rep. 2020 Sep 14;6(11):1132-1134. doi: 10.1016/j.jdcr.2020.08.034. eCollection 2020 Nov.
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Use of MALDI-TOF MS (Bruker Daltonics) for identification of Mycobacterium species isolated directly from liquid medium.应用 MALDI-TOF MS(布鲁克·道尔顿公司)直接从液体培养基中分离的分枝杆菌属菌种鉴定。
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Doxycycline, an Antibiotic or an Anti-Inflammatory Agent? The Most Common Uses in Dermatology.强力霉素,是抗生素还是抗炎药?皮肤科最常见的用途。
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Nontuberculous mycobacterial skin disease in cat; diagnosis and treatment - Case report.猫非结核分枝杆菌皮肤病;诊断与治疗——病例报告
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How to: identify non-tuberculous Mycobacterium species using MALDI-TOF mass spectrometry.方法:使用 MALDI-TOF 质谱法鉴定非结核分枝杆菌。
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Mycobacterial panniculitis caused by in a cat.猫身上由[具体病因未给出]引起的分枝杆菌性脂膜炎
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Orofacial granulomatosis responding to weekly azithromycin pulse therapy.对每周一次阿奇霉素冲击疗法有反应的口面部肉芽肿病
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