Petersen J K, Lück H, Kristensen F, Mikkelsen L
Int J Oral Surg. 1977 Feb;6(1):51-9. doi: 10.1016/s0300-9785(77)80059-8.
In a double-blind, cross-over, clinical study with nine probands, the efficiency parameters of four commonly used local analgesics were evaluated: 2% Carbocain with adrenaline 1:200,000, 3% Citanest with Octapressin 0.03 iu/mul, 3% Carbocain Dental, and 2% Xylocain with adrenaline 1:80,000. It was found that 3% Carbocain Dental (no vasoconstrictor content) demonstrated significantly shorter duration of analgesia than the other solutions in the soft tissues as well as in the dental pulp. 3% Citanest with Octapressin exhibited the longest soft tissue duration, but as far as duration of tooth analgesia was concerned there was no significant difference between 3% Carbocain Dental and 2% Carbocain with adrenaline. The longest duration of tooth analgesia was shown with 2% Xylocain with adrenaline; this solution also possessed the highest frequency of analgesia and extent of analgesia. All probands personally preferred injections with 3% Carbocain Dental as injection with this solution resulted in the least discomfort.
在一项针对9名受试者的双盲、交叉临床研究中，评估了四种常用局部麻醉剂的效能参数：含1:200,000肾上腺素的2%卡波卡因、含0.03 iu/mul奥曲肽的3%西他卡因、3%牙科用卡波卡因以及含1:80,000肾上腺素的2%利多卡因。结果发现，3%牙科用卡波卡因（不含血管收缩剂）在软组织和牙髓中的镇痛持续时间明显短于其他溶液。含奥曲肽的3%西他卡因软组织镇痛持续时间最长，但就牙齿镇痛持续时间而言，3%牙科用卡波卡因和含肾上腺素的2%卡波卡因之间无显著差异。含肾上腺素的2%利多卡因牙齿镇痛持续时间最长；该溶液的镇痛频率和镇痛范围也最高。所有受试者个人都更喜欢使用3%牙科用卡波卡因进行注射，因为使用该溶液注射带来的不适最少。
