嵌入手性药物的等离子体纳米结构的振动圆二色性

Vibrational circular dichroism of plasmonic nanostructures embedding chiral drugs.

作者信息

Adhikary Raju, Venturi Matteo, Salvitti Giovanna, Sahoo Ambaresh, Ferrante Carino, Benassi Paola, Di Stasio Francesco, Toma Andrea, Altug Hatice, Aschi Massimiliano, Marini Andrea

机构信息

Department of Physical and Chemical Sciences, University of L'Aquila, Via Vetoio, 67100, L'Aquila, Italy.

CNR-SPIN, c/o Dip.to di Scienze Fisiche e Chimiche, Via Vetoio, Coppito (L'Aquila), 67100, Italy.

出版信息

Sci Rep. 2025 Apr 16;15(1):13116. doi: 10.1038/s41598-025-97383-8.

DOI:10.1038/s41598-025-97383-8

PMID:40240459

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12003888/

Abstract

We investigate the mid-infrared chiroptical response of plasmonic nanostructures based on Al-doped ZnO and layers of an aqueous solution of Ladarixin, a chiral pharmaceutical currently under clinical trial for the treatment of type 1 diabetes. We explore the possibilities offered by localised surface plasmon resonances (LSPRs) for the enhancement of vibrational circular dichroism (VCD) of the considered chiral drug solution. Focusing on diverse plasmonic nanoshell geometries, we find that LSPRs provide an amplification factor of VCD differential absorption cross-section ranging from [Formula: see text] to [Formula: see text] thanks to near-field intensity enhancement produced by LSPRs. Our results indicate that nanoshell LSPRs are promising for probing molecular chirality at the nanoscale.

摘要

我们研究了基于掺铝氧化锌的等离子体纳米结构以及拉达列新水溶液层的中红外手性光学响应。拉达列新是一种目前正在进行治疗1型糖尿病临床试验的手性药物。我们探索了局域表面等离子体共振（LSPR）为增强所考虑的手性药物溶液的振动圆二色性（VCD）提供的可能性。聚焦于多种等离子体纳米壳几何结构，我们发现由于LSPR产生的近场强度增强，LSPR为VCD差分吸收截面提供了一个放大因子，范围从[公式：见原文]到[公式：见原文]。我们的结果表明，纳米壳LSPR在纳米尺度探测分子手性方面具有前景。